https://scholars.lib.ntu.edu.tw/handle/123456789/465767
標題: | Enhanced cell electro-permeabilisation combined with phototherapy to target-killing cancer cells by using multi functional carbon nanotubes | 作者: | Lee P.-C. MING-JIUM SHIEH |
關鍵字: | Carbon nanotubes; Electro-permeabilisation; Hyperthermia; Photodynamic therapy | 公開日期: | 2011 | 卷: | 3 | 起(迄)頁: | 379-381 | 來源出版物: | 2011 NSTI Nanotechnology Conference and Expo | 摘要: | Carbon nanotubes (CNTs) have been proposed and actively explored as multifunctional innovative carriers for drug delivery. This study presents a new modality for cell electro-permeabilisation based on the use of CNTs and external static electric fields to achieve highly drug delivery efficiency. Besides, CNTs are unique materials that absorb infrared (IR) radiation in the special spectral window where body tissues are most transparent. Absorbed IR promotes molecular oscillation leading to efficient heating of the surrounding environment. By using these characteristics of CNTs, we conjugated photosensitizers on chemically functionalized single-wall carbon nanotubes (f-SWNTs) to combine photodynamic therapy and hyperthermia for killing cancer cells specifically and effectively. Thus, CNT complex drug delivery is promising for improving the efficacy of drug delivery and treatment to decrease side effects for future cancer therapy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-81455143850&partnerID=40&md5=af2c5bea441bb8cbfb3d12c189839ca8 https://scholars.lib.ntu.edu.tw/handle/123456789/465767 |
SDG/關鍵字: | Body tissues; Cancer cells; Cancer therapy; Electro-permeabilisation; Functionalized; Hyperthermia; Molecular oscillations; Multi-functional; New modality; Phototherapy; Side effect; Static electric fields; Surrounding environment; Carbon; Carbon nanotubes; Cells; Diseases; Drug delivery; Electric fields; Fluidics; Hyperthermia therapy; Medical nanotechnology; Nanotechnology; Photodynamic therapy; Photosensitizers; Tissue; Single-walled carbon nanotubes (SWCN) |
顯示於: | 醫學工程學研究所 |
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