https://scholars.lib.ntu.edu.tw/handle/123456789/466082
標題: | The influences of adrenaline dosing frequency and dosage on outcomes of adult in-hospital cardiac arrest: A retrospective cohort study | 作者: | CHIH-HUNG WANG CHIEN-HUA HUANG WEI-TIEN CHANG MIN-SHAN TSAI Yu P.-H. YEN-WEN WU KUAN-YU HUNG WEN-JONE CHEN |
公開日期: | 2016 | 卷: | 103 | 起(迄)頁: | 125-130 | 來源出版物: | Resuscitation | 摘要: | Aim: To investigate the influence of dosing frequency and dosage of adrenaline on outcomes of cardiopulmonary resuscitation (CPR). Methods: We conducted a retrospective observational study in a single medical centre and included adult patients who had suffered an in-hospital cardiac arrest between 2006 and 2012. We used multivariable logistic regression analysis to evaluate the associations between independent variables and outcomes. Adrenaline average dosing frequency was calculated as the total dosage of adrenaline administered during CPR divided by the duration of CPR. Body weight (BW) was analysed as an interaction term to investigate the effect of adrenaline dosage on outcomes. Favourable neurological outcome was defined as a score of 1 or 2 on the Cerebral Performance Category scale at hospital discharge. Results: We included 896 patients in the analysis. After adjusting for multiple confounding factors, including CPR duration, the results indicated that higher adrenaline dosing frequency was associated with lower rates of survival (odds ratio (OR): 0.05, 95% confidence interval (CI): 0.01-0.23) and favourable neurological outcome at hospital discharge (OR: 0.02, 95% CI: 0.002-0.16). A significant interaction was noted between total adrenaline dosage and BW, which indicated that, with the same adrenaline dosage, the outcomes for patients with BW ? 82.5 kg would be worse than those for patients with lower BW. Conclusion: Higher adrenaline average dosing frequency may be associated with worse outcomes after CPR. Besides, according to current recommendations, patients with BW above 82.5 kg may not receive adequate dose of adrenaline. ? 2015 Elsevier Ireland Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/466082 | ISSN: | 0300-9572 | DOI: | 10.1016/j.resuscitation.2015.12.008 | SDG/關鍵字: | adrenalin; alpha adrenergic receptor stimulating agent; epinephrine; adult; Article; body weight; cohort analysis; controlled study; female; heart arrest; hospital discharge; hospitalization; human; in hospital cardiac arrest; major clinical study; male; observational study; priority journal; resuscitation; retrospective study; survival; aged; dose response; heart arrest; middle aged; mortality; procedures; statistical model; treatment outcome; very elderly; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Body Weight; Cardiopulmonary Resuscitation; Dose-Response Relationship, Drug; Epinephrine; Heart Arrest; Humans; Logistic Models; Middle Aged; Retrospective Studies; Treatment Outcome |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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