https://scholars.lib.ntu.edu.tw/handle/123456789/466106
標題: | Safety and six-month durability of angioplasty for isolated penile artery stenoses in patients with erectile dysfunction: A first-in-man study | 作者: | TZUNG-DAU WANG WEN-JENG LEE Yang S.-C. Lin P.-C. Tai H.-C. Hsieh J.T. SHIH-PING LIU CHIEN-HUA HUANG WEN-JONE CHEN MING-FONG CHEN |
公開日期: | 2014 | 卷: | 10 | 期: | 1 | 起(迄)頁: | 147-156 | 來源出版物: | EuroIntervention | 摘要: | Aims: Obstructive pelvic arterial lesions are highly prevalent in patients with erectile dysfunction and commonly located in penile artery segments. In this first-in-man study, we intended to assess the safety and feasibility of balloon angioplasty for isolated penile artery stenoses in patients with erectile dysfunction. Methods and results: Twenty-five patients with erectile dysfunction and isolated penile artery stenoses (unilateral stenosis ?70% or bilateral stenoses ?50%) identified by pelvic computed tomographic angiography were enrolled. A total of 20 patients (mean age 61 years [range, 48-79 years]) underwent balloon angioplasty. Three patients had bilateral penile artery stenoses. Procedural success was achieved in all 23 penile arteries, with an average balloon size of 1.6 mm (range, 1.00-2.25 mm). The average International Index for Erectile Function-5 (IIEF-5) score improved from 10.0±5.2 at baseline to 15.2±6.7 (p>0.001) at one month and 15.2±6.3 (p>0.001) at six months. Clinical success (change in the IIEF-5 score ?4 or normalisation of erectile function [IIEF-5 ?22]) was achieved in 15 (75%), 13 (65%), and 12 (60%) patients at one, three, and six months, respectively. There were no adverse events through follow-up. Conclusions: For the first time we demonstrated that penile artery angioplasty is safe and can achieve clinically significant improvement in erectile function in 60% of patients with erectile dysfunction and isolated penile artery stenoses. ? Europa Digital & Publishing 2014. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/466106 | ISSN: | 1774-024X | DOI: | 10.4244/EIJV10I1A23 | SDG/關鍵字: | adult; aged; artery occlusion; article; clinical article; clinical effectiveness; clinical trial; computed tomographic angiography; computed tomography scanner; erectile dysfunction; first in human study; human; International Index of Erectile Function; isolated penile artery stenosis; male; middle aged; penis disease; percutaneous transluminal angioplasty; cohort analysis; complication; Constriction, Pathologic; feasibility study; Impotence, Vasculogenic; penis; percutaneous transluminal angioplasty; Peripheral Arterial Disease; procedures; treatment outcome; vascularization; Aged; Angioplasty, Balloon; Cohort Studies; Constriction, Pathologic; Feasibility Studies; Humans; Impotence, Vasculogenic; Male; Middle Aged; Penis; Peripheral Arterial Disease; Treatment Outcome |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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