https://scholars.lib.ntu.edu.tw/handle/123456789/467661
標題: | Corylin suppresses hepatocellular carcinoma progression via the inhibition of epithelial-mesenchymal transition, mediated by long noncoding RNA GAS5 | 作者: | Chen C.-Y. Chen C.-C. Shieh T.-M. Hsueh C. SHU-HUEI WANG Leu Y.-L. Lian J.-H. Wang T.-H. |
公開日期: | 2018 | 出版社: | MDPI AG | 卷: | 19 | 期: | 2 | 起(迄)頁: | 380 | 來源出版物: | International Journal of Molecular Sciences | 摘要: | Corylin is a flavonoid extracted from the nuts of Psoralea corylifolia L. (Fabaceae), which is a widely used anti-inflammatory and anticancer herb in China. Recent studies revealed antioxidant, anti-inflammatory, and bone differentiation-promoting effects of corylin. However, there are no studies examining the anticancer activity of corylin. In this study, we used cells and animal models to examine the antitumor effects of corylin on hepatocellular carcinoma (HCC) and then studied its downstream regulatory mechanisms. The results showed that corylin significantly inhibited the proliferation, migration, and invasiveness of HCC cells and suppressed epithelial-mesenchymal transition. We found that the anti-HCC mechanism of corylin’s action lies in the upregulation of tumor suppressor long noncoding RNA growth arrest-specific transcript 5 (GAS5) and the activation of its downstream anticancer pathways. In animal experiments, we also found that corylin can significantly inhibit tumor growth without significant physiological toxicity. The above results suggest that corylin has anti-HCC effects and good potential as a clinical treatment. ? 2018 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041105200&doi=10.3390%2fijms19020380&partnerID=40&md5=d395bc6fb66cb266f923387ab5dd595e https://scholars.lib.ntu.edu.tw/handle/123456789/467661 |
ISSN: | 1661-6596 | DOI: | 10.3390/ijms19020380 | SDG/關鍵字: | antineoplastic agent; corylin; flavonoid; long noncoding RNA growth arrest specific transcript 5; long untranslated RNA; unclassified drug; antineoplastic agent; corylin; flavonoid; growth arrest specific transcript 5; small nucleolar RNA; animal experiment; animal model; animal tissue; antineoplastic activity; antiproliferative activity; Article; cancer inhibition; controlled study; drug mechanism; epithelial mesenchymal transition; in vitro study; in vivo study; liver cell carcinoma; male; metastasis inhibition; mouse; nonhuman; tumor invasion; upregulation; animal; Bagg albino mouse; drug effect; epithelial mesenchymal transition; genetics; Hep-G2 cell line; human; liver cell carcinoma; liver tumor; nude mouse; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Epithelial-Mesenchymal Transition; Flavonoids; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; RNA, Small Nucleolar |
顯示於: | 解剖學暨細胞生物學科所 |
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