https://scholars.lib.ntu.edu.tw/handle/123456789/467739
標題: | Prognostic value of intrathecal heme oxygenase-1 concentration in patients with Fisher Grade III aneurysmal subarachnoid hemorrhage | 作者: | KUO-CHUAN WANG SUNG-CHUN TANG Lee J.-E. DAR-MING LAI Huang S.-J. SUNG-TSANG HSIEH JIANN-SHING JENG YONG-KWANG TU |
公開日期: | 2014 | 出版社: | American Association of Neurological Surgeons | 卷: | 121 | 期: | 6 | 起(迄)頁: | 1388 | 來源出版物: | Journal of Neurosurgery | 摘要: | Object. Experimental studies have demonstrated the crucial role of posthemorrhagic erythrocyte catabolism in the pathogenesis of subarachnoid hemorrhage (SAH). The authors of this study aimed to investigate the prognostic value of a series of CSF biomarkers linked to heme metabolism in SAH patients. Methods. Patients with Fisher Grade III aneurysmal SAH undergoing early aneurysm obliteration were enrolled. The levels of heme oxygenase-1 (HO-1), oxyhemoglobin, ferritin, and bilirubin in intrathecal CSF were measured on the 7th day posthemorrhage. The associations of functional outcome with clinical and CSF parameters were analyzed. Results. The study included 41 patients (mean age 59 ± 14 years; 16 male, 25 female), 17 (41.5%) of whom had an unfavorable outcome (Glasgow Outcome Scale score ? 3) 3 months after SAH. In terms of the clinical data, age > 60 years, admission World Federation of Neurosurgical Societies Grade ? III, and the presence of acute hydrocephalus were independent factors associated with an unfavorable outcome. After adjusting for clinical parameters, a higher level of HO-1 appeared to be the most significant CSF parameter related to an unfavorable outcome among all tested CSF molecules (OR 0.934, 95% CI 0.883-0.989, p = 0.018). Further analysis using a generalized additive model identified a cutoff HO-1 value of 81.2 μM, with higher values predicting unfavorable outcome (82.4% accuracy). Conclusions. The authors propose that the level of intrathecal CSF HO-1 at Day 7 post-SAH can be an effective outcome indicator in patients with Fisher Grade III aneurysmal SAH. ?AANS, 2014. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84986877519&doi=10.3171%2f2014.7.JNS131704&partnerID=40&md5=424ce349cfcc27505f86d35ed3bec7e2 https://scholars.lib.ntu.edu.tw/handle/123456789/467739 |
ISSN: | 0022-3085 | DOI: | 10.3171/2014.7.JNS131704 | SDG/關鍵字: | bilirubin; ferritin; heme oxygenase 1; lactic acid; oxyhemoglobin; bilirubin; biological marker; ferritin; heme oxygenase 1; HMOX1 protein, human; oxyhemoglobin; acute disease; adult; Article; cerebrospinal fluid; clinical article; computed tomographic angiography; computer assisted tomography; concentration (parameters); diagnostic accuracy; diagnostic value; enzyme metabolism; female; fisher grade; Glasgow outcome scale; human; hydrocephalus; male; mental deterioration; neuroimaging; outcome assessment; predictive value; priority journal; scoring system; sensitivity and specificity; subarachnoid hemorrhage; adolescent; aged; enzymology; hydrocephalus; middle aged; prognosis; severity of illness index; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Bilirubin; Biological Markers; Female; Ferritins; Heme Oxygenase-1; Humans; Hydrocephalus; Male; Middle Aged; Oxyhemoglobins; Prognosis; Severity of Illness Index; Subarachnoid Hemorrhage; Young Adult |
顯示於: | 解剖學暨細胞生物學科所 |
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