https://scholars.lib.ntu.edu.tw/handle/123456789/467762
標題: | European Federation of Neurological Societies/Peripheral Nerve Society guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society | 作者: | Lauria G. SUNG-TSANG HSIEH Johansson O. Kennedy W.R. Leger J.-M. Mellgren S.I. Nolano M. Merkies I.S.J. Polydefkis M. Smith A.G. Sommer C. Valls-Sole J. |
公開日期: | 2010 | 卷: | 15 | 期: | 2 | 起(迄)頁: | 79-92 | 來源出版物: | Journal of the Peripheral Nervous System | 摘要: | Revision of the guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy, published in 2005, has become appropriate due to publication of more relevant papers. Most of the new studies focused on small fiber neuropathy (SFN), a subtype of neuropathy for which the diagnosis was first developed through skin biopsy examination. This revision focuses on the use of this technique to diagnose SFN. Task force members searched the Medline database from 2005, the year of the publication of the first EFNS guideline, to June 30th, 2009. All pertinent papers were rated according to the EFNS and PNS guidance. After a consensus meeting, the task force members created a manuscript that was subsequently revised by two experts (JML and JVS) in the field of peripheral neuropathy and clinical neurophysiology, who were not previously involved in the use of skin biopsy. Distal leg skin biopsy with quantification of the linear density of intraepidermal nerve fibers (IENF), using generally agreed upon counting rules, is a reliable and efficient technique to assess the diagnosis of SFN (level A recommendation). Normative reference values are available for bright-field immunohistochemistry (level A recommendation) but not yet for confocal immunofluorescence or the blister technique. The morphometric analysis of IENF density, either performed with bright-field or immunofluorescence microscopy, should always refer to normative values matched for age (level A recommendation). Newly established laboratories should undergo adequate training in a well established skin biopsy laboratory and provide their own stratified age and gender-matched normative values, intra- and interobserver reliability, and interlaboratory agreement. Quality control of the procedure at all levels is mandatory (Good Practice Point). Procedures to quantify subepidermal nerve fibers and autonomic innervated structures, including erector pili muscles, and skin vessels are under development but need to be confirmed by further studies. Sweat gland innervation can be examined using an unbiased stereologic technique recently proposed (level B recommendation). A reduced IENF density is associated with the risk of developing neuropathic pain (level B recommendation), but it does not correlate with its intensity. Serial skin biopsies might be useful for detecting early changes of IENF density, which predict the progression of neuropathy, and to assess degeneration and regeneration of IENF (level C recommendation). However, further studies are warranted to confirm the potential usefulness of skin biopsy with measurement of IENF density as an outcome measure in clinical practice and research. Skin biopsy has not so far been useful for identifying the etiology of SFN. Finally, we emphasize that 3-mm skin biopsy at the ankle is a safe procedure based on the experience of 10 laboratories reporting absence of serious side effects in approximately 35,000 biopsies and a mere 0.19% incidence of non-serious side effects in about 15 years of practice (Good Practice Point). ? 2010 Peripheral Nerve Society and European Federation of Neurological Societies. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954296006&doi=10.1111%2fj.1529-8027.2010.00269.x&partnerID=40&md5=7332025ee45a605dee1ad1bf2356c479 https://scholars.lib.ntu.edu.tw/handle/123456789/467762 |
ISSN: | 1085-9489 | DOI: | 10.1111/j.1529-8027.2010.00269.x | SDG/關鍵字: | age; autonomic innervation; cell count; cell density; consensus development; disease course; Europe; evoked response; good clinical practice; human; immunohistochemistry; interrater reliability; medical society; MEDLINE; morphometrics; nerve biopsy; nerve cell; nerve cell degeneration; nerve fiber; nerve regeneration; neuropathic pain; patient safety; peripheral neuropathy; practice guideline; prediction; priority journal; quality control; reference value; review; sensory nerve conduction; sex difference; skin biopsy; skin blood vessel; stereology; sural nerve; sweat gland; Biopsy; Consensus; Humans; Nerve Fibers; Neural Conduction; Peripheral Nerves; Peripheral Nervous System Diseases; Reference Values; Skin |
顯示於: | 解剖學暨細胞生物學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。