https://scholars.lib.ntu.edu.tw/handle/123456789/467792
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | VIN-CENT WU | en_US |
dc.contributor.author | JENQ-WEN HUANG | en_US |
dc.contributor.author | HUANG-CHUN LIEN | en_US |
dc.contributor.author | SUNG-TSANG HSIEH | en_US |
dc.contributor.author | HON-MAN LIU | en_US |
dc.contributor.author | Yang C.-C. | en_US |
dc.contributor.author | YEN-HUNG LIN | en_US |
dc.contributor.author | HWANG, JUEY-JEN | en_US |
dc.contributor.author | KWAN-DUN WU | en_US |
dc.creator | Wu V.-C.;Huang J.-W.;Lien H.-C.;Sung-Tsang Hsieh;Liu H.-M.;Yang C.-C.;Lin Y.-H.;Hwang J.-J.;Wu K.-D. | - |
dc.date.accessioned | 2020-03-02T08:11:24Z | - |
dc.date.available | 2020-03-02T08:11:24Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746296478&doi=10.1097%2f01.md.0000230250.95281.60&partnerID=40&md5=f6da31febfa858e1d62ed6d193e1fe76 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/467792 | - |
dc.description.abstract | Levamisole (LEV) has been used as an immunomodulating medication in patients with recurrent aphthous ulcers and as an adjuvant for chemotherapy. LEV, with or without 5-fluorouracil (5-FU), induces multifocal inflammatory leukoencephalopathy (MIL). We identified 31 patients with LEV-induced MIL: 7 from our institution and 24 from a MEDLINE search. Twenty-one patients (67.7%) had been treated with a combination of LEV and 5-FU, while 10 patients had been treated with LEV alone. The onset of MIL was delayed in patients who took LEV and 5-FU in combination compared with the patients treated with LEV alone (11.7 ± 3.7 vs. 4 ± 2.5 wk, p < 0.001). Colon cancer (67.7%) was the most common indication for LEV administration. Gait ataxia occurred in 20 (64.5%) patients, and dysphagia was noted in 16 (51.6%) patients. Imaging studies revealed periventricular enhancement in 17 (54.8%) patients and supratentorial lesions in 16 (51.6%) patients. Cerebrospinal fluid studies showed lymphocytic pleocytosis in 10 of 21 (47.6%) patients. Early diagnosis of MIL and discontinuation of LEV is essential, yielding good recovery in most cases. Treatment with corticosteroids and/or intravenous immunoglobulin may be needed for this serious inflammatory encephalopathy. Twenty-nine patients exhibited improved clinical status and imaging findings after initial steroid or immunoglobulin treatment. Plasmapheresis may be an alternative regimen for patients with steroid resistance. Copyright ? 2006 by Lippincott Williams & Wilkins. | en_US |
dc.relation.ispartof | Medicine | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | betamethasone; corticosteroid; dexamethasone; fluorouracil; immunoglobulin; levamisole; methylprednisolone; prednisolone; steroid; adjuvant chemotherapy; aphasia; aphthous ulcer; article; ataxia; Babinski reflex; brain tumor; cerebrospinal fluid; clinical feature; cognitive defect; colon cancer; confusion; convalescence; diplopia; disease severity; drug indication; drug pulse therapy; drug withdrawal; dysarthria; dysphagia; early diagnosis; facial nerve paralysis; feces incontinence; gait disorder; health status; hemiparesis; human; hyperreflexia; hypersomnia; hyporeflexia; immunomodulation; information retrieval; lassitude; leukoencephalopathy; MEDLINE; monotherapy; motor dysfunction; mouth ulcer; muscle spasm; mutism; neuroimaging; neurologic disease; nuclear magnetic resonance imaging; pemphigus vulgaris; plasmapheresis; pleocytosis; priority journal; quadriplegia; seizure; side effect; statistical analysis; steroid therapy; treatment duration; treatment outcome; tremor; urine incontinence; Adult; Aged; Colonic Neoplasms; Female; Humans; Leukoencephalopathy, Progressive Multifocal; Levamisole; Male; Middle Aged; Plasmapheresis; Steroids; Treatment Outcome | - |
dc.title | Levamisole-induced multifocal inflammatory leukoencephalopathy: Clinical characteristics, outcome, and impact of treatment in 31 patients | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1097/01.md.0000230250.95281.60 | - |
dc.identifier.pmid | 16862045 | - |
dc.identifier.scopus | 2-s2.0-33746296478 | - |
dc.relation.pages | 203-213 | en_US |
dc.relation.journalvolume | 85 | en_US |
dc.relation.journalissue | 4 | en_US |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Anatomy and Cell Biology | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-7935-0991 | - |
crisitem.author.orcid | 0000-0001-8011-2317 | - |
crisitem.author.orcid | 0000-0003-1472-1231 | - |
crisitem.author.orcid | 0000-0002-3188-8482 | - |
crisitem.author.orcid | 0000-0001-6715-6366 | - |
crisitem.author.orcid | 0000-0001-8153-1441 | - |
crisitem.author.orcid | 0000-0001-6437-0455 | - |
crisitem.author.orcid | 0000-0002-3339-1509 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 解剖學暨細胞生物學科所 |
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