https://scholars.lib.ntu.edu.tw/handle/123456789/467808
標題: | Neuromuscular disorders in severe acute respiratory syndrome | 作者: | LI-KAI TSAI SUNG-TSANG HSIEH CHI-CHAO CHAO YEE-CHUN CHEN Lin Y.-H. SHAN-CHWEN CHANG Chang Y.-C. |
公開日期: | 2004 | 卷: | 61 | 期: | 11 | 起(迄)頁: | 1669-1673 | 來源出版物: | Archives of Neurology | 摘要: | Objective: To delineate and clarify neuromuscular disorders in patients with probable severe acute respiratory syndrome (SARS). Design: Case series with follow-up ranging from 3 weeks to 2 months. Setting: National Taiwan University Hospital, Taipei. Patients: We investigated 4 patients with SARS who had concomitant neuromuscular problems. A diagnosis of SARS was based on the demonstration of serum coronavirus antibodies. Clinical presentations, laboratory results, electrophysiologic findings, and follow-up conditions were determined. Results: Patients developed neuromuscular problems approximately 3 weeks after the onset of SARS. Two women experienced motor-predominant peripheral nerve disorders. A man developed myopathy and a third woman experienced neuropathy and myopathy. Cerebrospinal fluid obtained from 2 patients with neuropathy disclosed normal protein content and the absence of pleocytosis and SARS coronavirus antibodies. Both patients with myopathy had elevated serum creatine kinase levels. A rapid clinical and electrophysiologic improvement was evident during follow-up examinations, with a good prognosis. Conclusions: The neuromuscular problems in patients with SARS are considered to be critical-illness polyneuropathy or myopathy, possibly coexistent. Further pathological and microbiological studies are necessary to determine the relationship between SARS coronavirus and neuromuscular problems. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-7744235658&doi=10.1001%2farchneur.61.11.1669&partnerID=40&md5=0c489cc11bda953254976a33d48deb4e https://scholars.lib.ntu.edu.tw/handle/123456789/467808 |
ISSN: | 0003-9942 | DOI: | 10.1001/archneur.61.11.1669 | SDG/關鍵字: | cefepime; cefotaxime; ciprofloxacin; cisatracurium; clarithromycin; clindamycin; creatine kinase; fluconazole; imipenem; levofloxacin; methylprednisolone; minocycline; moxifloxacin; oxacillin; ribavirin; vancomycin; virus antibody; adult; antibody blood level; article; case report; case study; clinical feature; Coronavirus; disease association; enzyme blood level; female; follow up; human; laboratory test; male; myopathy; peripheral neuropathy; pleocytosis; polyneuropathy; priority journal; protein cerebrospinal fluid level; severe acute respiratory syndrome; Adult; Cerebrospinal Fluid; Electrophysiology; Female; Humans; Male; Middle Aged; Neuromuscular Diseases; Severe Acute Respiratory Syndrome |
顯示於: | 解剖學暨細胞生物學科所 |
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