https://scholars.lib.ntu.edu.tw/handle/123456789/467893
標題: | Effect of Kidney Dysfunction on Cerebral Cortical Thinning in Elderly Population | 作者: | CHIH-HAO CHEN YA-FANG CHEN MING-JANG CHIU TA-FU CHEN Tsai P.-H. JEN-HAU CHEN CHUNG-JEN YEN SUNG-CHUN TANG SHIN-JOE YEH YEN-CHING CHEN |
公開日期: | 2017 | 卷: | 7 | 期: | 1 | 起(迄)頁: | 2337 | 來源出版物: | Scientific Reports | 摘要: | Chronic kidney disease has been linked to cognitive impairment and morphological brain change. However, less is known about the impact of kidney functions on cerebral cortical thickness. This study investigated the relationship between kidney functions and global or lobar cerebral cortical thickness (CTh) in 259 non-demented elderly persons. Forty-Three participants (16.7%) had kidney dysfunction, which was defined as either a glomerular filtration rate (GFR) of <60 ml/min/1.73 m2 or presence of proteinuria. Kidney dysfunction was associated with lower global (β =-0.05, 95% CI =-0.08 to-0.01) as well as frontal, parietal, temporal, occipital, and insular lobar CTh. In the stratified analysis, the associations were more pronounced in women, APOE?4 non-carriers, and participants with a lower cognitive score. Besides, kidney dysfunction significantly increased the risk of cortical thinning, defined as being the lowest CTh tertile, in the insular lobe (adjusted odds ratio = 2.74, 95% CI = 1.31-5.74). Our results suggested that kidney dysfunction should be closely monitored and managed in elderly population to prevent neurodegeneration. ? 2017 The Author(s). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/467893 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-017-02537-y | SDG/關鍵字: | aged; brain cortex; chronic kidney failure; cognitive defect; complication; diagnostic imaging; female; glomerulus filtration rate; human; kidney failure; male; middle aged; nuclear magnetic resonance imaging; pathophysiology; physiology; risk factor; Aged; Cerebral Cortex; Cognitive Dysfunction; Female; Glomerular Filtration Rate; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Renal Insufficiency; Renal Insufficiency, Chronic; Risk Factors |
顯示於: | 醫學系 |
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