|Title:||Endothelial progenitor cell dysfunction in cardiovascular diseases: Role of reactive oxygen species and inflammation||Authors:||Lin C.-P.
|Issue Date:||2013||Journal Volume:||2013||Start page/Pages:||845037||Source:||BioMed Research International||Abstract:||
Endothelial progenitor cells (EPCs) move towards injured endothelium or inflamed tissues and incorporate into foci of neovascularisation, thereby improving blood flow and tissue repair. Patients with cardiovascular diseases have been shown to exhibit reduced EPC number and function. It has become increasingly apparent that these changes may be effected in response to enhanced oxidative stress, possibly as a result of systemic and localised inflammatory responses. The interplay between inflammation and oxidative stress affects the initiation, progression, and complications of cardiovascular diseases. Recent studies suggest that inflammation and oxidative stress modulate EPC bioactivity. Clinical medications with anti-inflammatory and antioxidant properties, such as statins, thiazolidinediones, angiotensin II receptor 1 blockers, and angiotensin-converting enzyme inhibitors, are currently administered to patients with cardiovascular diseases. These medications appear to exert beneficial effects on EPC biology. This review focuses on EPC biology and explores the links between oxidative stress, inflammation, and development of cardiovascular diseases. ? 2013 Chih-Pei Lin et al.
|ISSN:||2314-6133||DOI:||10.1155/2013/845037||SDG/Keyword:||reactive oxygen metabolite; reactive oxygen metabolite; reactive oxygen metabolite; angiogenesis; atherogenesis; cardiovascular disease; cell function; endothelial progenitor cell; human; inflammation; nonhuman; oxidative stress; review; animal; endothelium cell; inflammation; metabolism; oxidative stress; pathology; stem cell; cardiovascular disease; endothelium cell; metabolism; stem cell; Animals; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Oxidative Stress; Reactive Oxygen Species; Stem Cells; Animals; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Oxidative Stress; Reactive Oxygen Species; Stem Cells
|Appears in Collections:||解剖學暨細胞生物學科所|
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