https://scholars.lib.ntu.edu.tw/handle/123456789/468513
標題: | Gallic acid attenuates platelet activation and platelet-leukocyte aggregation: Involving pathways of Akt and GSK3β | 作者: | Chang S.-S. Lee V.S.Y. Tseng Y.-L. Chang K.-C. Chen K.-B. YUH-LIEN CHEN Li C.-Y. |
公開日期: | 2012 | 卷: | 2012 | 起(迄)頁: | 683872 | 來源出版物: | Evidence-based Complementary and Alternative Medicine | 摘要: | Platelet activation and its interaction with leukocytes play an important role in atherothrombosis. Cardiovascular diseases resulted from atherothrombosis remain the major causes of death worldwide. Gallic acid, a major constituent of red wine and tea, has been believed to have properties of cardiovascular protection, which is likely to be related to its antioxidant effects. Nonetheless, there were few and inconsistent data regarding the effects of gallic acid on platelet function. Therefore, we designed this in vitro study to determine whether gallic acid could inhibit platelet activation and the possible mechanisms. From our results, gallic acid could concentration-dependently inhibit platelet aggregation, P-selectin expression, and platelet-leukocyte aggregation. Gallic acid prevented the elevation of intracellular calcium and attenuated phosphorylation of PKCα/p38 MAPK and Akt/GSK3β on platelets stimulated by the stimulants ADP or U46619. This is the first mechanistic explanation for the inhibitory effects on platelets from gallic acid. ? Copyright 2012 Shih-Sheng Chang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864962166&doi=10.1155%2f2012%2f683872&partnerID=40&md5=dbe72edf63ea50555fd5941506451895 https://scholars.lib.ntu.edu.tw/handle/123456789/468513 |
ISSN: | 1741-427X | DOI: | 10.1155/2012/683872 | SDG/關鍵字: | 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid; adenosine diphosphate; calcium; gallic acid; glycogen synthase kinase 3beta; mitogen activated protein kinase p38; PADGEM protein; protein kinase B; protein kinase C alpha; article; calcium cell level; concentration response; drug determination; drug effect; drug mechanism; human; human cell; in vitro study; leukocyte aggregation inhibition; leukocyte function; priority journal; protein expression; protein phosphorylation; thrombocyte aggregation inhibition |
顯示於: | 解剖學暨細胞生物學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。