|Title:||Role of pigment epithelium-derived factor in stem/progenitor cell-associated neovascularization||Authors:||Liu J.-T.
|Issue Date:||2012||Journal Volume:||2012||Start page/Pages:||871272||Source:||Journal of Biomedicine and Biotechnology||Abstract:||
Pigment epithelium-derived factor (PEDF) was first identified in retinal pigment epithelium cells. It is an endogenously produced protein that is widely expressed throughout the human body such as in the eyes, liver, heart, and adipose tissue; it exhibits multiple and varied biological activities. PEDF is a multifunctional protein with antiangiogenic, antitumorigenic, antioxidant, anti-inflammatory, antithrombotic, neurotrophic, and neuroprotective properties. More recently, PEDF has been shown to be the most potent inhibitor of stem/progenitor cell-associated neovascularization. Neovascularization is a complex process regulated by a large, interacting network of molecules from stem/progenitor cells. PEDF is also involved in the pathogenesis of angiogenic eye disease, tumor growth, and cardiovascular disease. Novel antiangiogenic agents with tolerable side effects are desired for the treatment of patients with various diseases. Here, we review the value of PEDF as an important endogenous antiangiogenic molecule; we focus on the recently identified role of PEDF as a possible new target molecule to influence stem/progenitor cell-related neovascularization. Copyright ? 2012 Jung-Tung Liu et al.
|ISSN:||1110-7243||DOI:||10.1155/2012/871272||SDG/Keyword:||angiogenesis inhibitor; pigment epithelium derived factor; eye protein; nerve growth factor; pigment epithelium derived factor; pigment epithelium-derived factor; serine proteinase inhibitor; angiogenesis; blindness; cardiovascular disease; human; neovascularization (pathology); pathogenesis; retina neovascularization; review; stem cell; subretinal neovascularization; angiogenesis; animal; cytology; physiology; Animals; Eye Proteins; Humans; Neovascularization, Physiologic; Nerve Growth Factors; Serpins; Stem Cells
|Appears in Collections:||解剖學暨細胞生物學科所|
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