|Title:||Magnolol: A multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis||Authors:||Chen Y.-H.
|Issue Date:||2011||Publisher:||Elsevier GmbH||Journal Volume:||3||Journal Issue:||4||Start page/Pages:||e317-e324||Source:||European Journal of Integrative Medicine||Abstract:||
Introduction: Chinese herbs are widely used as important remedies in Oriental integrative medicine. Magnolol is a small polyphenolic molecule with low toxicity that is isolated from the herb genus Magnolia. In preclinical experiments, magnolol was found to have anti-oxidative, anti-inflammatory, anti-tumorigenic, anti-diabetic, anti-microbial, anti-neurodegenerative and anti-depressant properties. Magnolol can also effectively regulate pain control, hormonal signalling, gastrointestinal and uterus modulation as well as provide cardiovascular and liver protective effects. Materials and methods: We briefly conducted PubMed and MEDLINE database reviews for articles that related to magnolol. Results: The major biological mechanisms of action and potential health benefits of magnolol are described. Conclusions: These health benefits of magnolol have provided an increased interest in bringing this herbal compound to the clinic as a novel therapeutic agent. Knowledge of the multiple activities of magnolol can assist with the development of magnolol derivatives and the design of clinical trials that will maximize the potential benefit of magnolol in the patient setting. ? 2011.
|ISSN:||1876-3820||DOI:||10.1016/j.eujim.2011.09.002||SDG/Keyword:||basic fibroblast growth factor receptor; hydroxyl radical; immunoglobulin enhancer binding protein; interleukin 4; Magnolia officinalis extract; magnolol; myeloperoxidase; tumor necrosis factor alpha; acute liver failure; adipocyte; anaphylaxis; antiinflammatory activity; antimicrobial activity; antineoplastic activity; antioxidant activity; asthma; atherosclerosis; bacterial infection; cell adhesion; chest tightness; Chinese medicine; depression; drug effect; drug mechanism; electroencephalogram; enzyme activity; fibroblast; fibrosarcoma; gene mutation; heart muscle cell; herbal medicine; human; inflammation; lipid peroxidation; liver injury; liver metastasis; liver mitochondrion; lung cancer; Magnoliaceae; medicinal plant; Medline; melanoma; motor cortex; mycosis; nerve degeneration; non insulin dependent diabetes mellitus; nonhuman; pain; photoaging; priority journal; restenosis; review; skin edema; smooth muscle contraction; smooth muscle fiber; thyroid carcinoma
|Appears in Collections:||解剖學暨細胞生物學科所|
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