https://scholars.lib.ntu.edu.tw/handle/123456789/468528
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Liu P.-L. | en_US |
dc.contributor.author | Tsai J.-R. | en_US |
dc.contributor.author | Hwang J.-J. | en_US |
dc.contributor.author | Chou S.-H. | en_US |
dc.contributor.author | Cheng Y.-J. | en_US |
dc.contributor.author | Lin F.-Y. | en_US |
dc.contributor.author | YUH-LIEN CHEN | en_US |
dc.contributor.author | Hung C.-Y. | en_US |
dc.contributor.author | Chen W.-C. | en_US |
dc.contributor.author | Chen Y.-H. | en_US |
dc.contributor.author | Chong I.-W. | en_US |
dc.creator | Liu P.-L.;Tsai J.-R.;Hwang J.-J.;Chou S.-H.;Cheng Y.-J.;Lin F.-Y.;Yuh-Lien Chen;Hung C.-Y.;Chen W.-C.;Chen Y.-H.;Chong I.-W. | - |
dc.date.accessioned | 2020-03-03T02:28:40Z | - |
dc.date.available | 2020-03-03T02:28:40Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1044-1549 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78149273733&doi=10.1165%2frcmb.2009-0269OC&partnerID=40&md5=5438249024cbf04b7753b6b8f8252b65 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/468528 | - |
dc.description.abstract | High-mobility group box 1 (HMGB1) is a versatile protein with intranuclear and extracellular functions. It is involved in invasion and metastasis in various human malignancies. However, the role of HMGB1 in non-small cell lung cancer (NSCLC) is unclear. We hypothesized that HMGB1 expression is a determinant of cellular invasiveness and metastasis in lung cancer. We examined HMGB1 expression in 48 NSCLC specimens by quantitative real-time PCR. High HMGB1 expression was significantly associated with clinically advanced stages (stage III-IV) (P < 0.05) and was correlated to expression of matrix metalloproteinase-9 (MMP-9) (P < 0.05). Patients with high levels of HMGB1 expression had poorer clinical prognosis. The expression level of MMP-9 and metastatic ability in vitro were significantly higher in an HMGB1-overexpressing human NSCLC cell lines (A549 and H23). The treatment with HMGB1 small interfering RNA reduced MMP-9 expression and the cellular metastatic ability in NSCLC cells. We also demonstrated that phosphoinositide 3-kinase/Akt and NF-κB-related pathways contributed to the HMGB1-induced MMP-9 expression and cellular metastatic ability. | - |
dc.relation.ispartof | American Journal of Respiratory Cell and Molecular Biology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | gelatinase A; gelatinase B; high mobility group B1 protein; immunoglobulin enhancer binding protein; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase p38; phosphatidylinositol 3 kinase; protein kinase B; small interfering RNA; stress activated protein kinase 1; gelatinase A; gelatinase B; high mobility group B1 protein; immunoglobulin enhancer binding protein; messenger RNA; mitogen activated protein kinase; MMP2 protein, human; phosphatidylinositol 3 kinase; protein kinase B; adult; advanced cancer; aged; article; cancer survival; cell invasion; cell migration; clinical article; controlled study; enzyme activity; female; gene expression; gene silencing; human; human cell; human tissue; lung non small cell cancer; male; metastasis; metastasis potential; prognosis; protein expression; cancer invasion; cell motion; enzyme activation; enzymology; gene expression regulation; genetics; lung tumor; metabolism; middle aged; pathology; tumor cell line; 1-Phosphatidylinositol 3-Kinase; Adult; Aged; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; HMGB1 Protein; Humans; Lung Neoplasms; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; NF-kappa B; Proto-Oncogene Proteins c-akt; RNA, Messenger | - |
dc.title | High-mobility group box 1-mediated matrix metalloproteinase-9 expression in non-small cell lung cancer contributes to tumor cell invasiveness | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1165/rcmb.2009-0269OC | - |
dc.identifier.pmid | 19933377 | - |
dc.identifier.scopus | 2-s2.0-78149273733 | - |
dc.relation.pages | 530-538 | - |
dc.relation.journalvolume | 43 | - |
dc.relation.journalissue | 5 | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
crisitem.author.dept | Anatomy and Cell Biology | - |
crisitem.author.orcid | 0000-0002-6498-4008 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 解剖學暨細胞生物學科所 |
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