https://scholars.lib.ntu.edu.tw/handle/123456789/468542
標題: | In search of antioxidants and anti-atherosclerotic agents from herbal medicines | 作者: | Shiao M.-S. Chiu J.-J. Chang B.-W. Wang J. Jen W.-P. Wu Y.-J. YUH-LIEN CHEN |
公開日期: | 2008 | 卷: | 34 | 期: | 2 | 起(迄)頁: | 147-157 | 來源出版物: | BioFactors | 摘要: | Many recent studies have suggested that low-density lipoprotein (LDL) oxidation, endothelial dysfunction, and inflammation are involved in the pathogenesis of atherosclerosis. Herbal regimens in the treatment of blood stasis, a counterpart of atherosclerosis, commonly use medicinal plants of leguminosae and labiatae. We have developed disease-oriented screening methods to search for bioactive components, particularly isoflavones in leguminosae and polyphenols in labiatae from Chinese herbal medicines. Many bioactive components and active fractions capable of inhibiting a. Cu(II)-induced LDL oxidation, b. oxidized LDL-induced endothelial damage, c. uptake of oxidized LDL by macrophages (J774A.1), and d. expression of cell adhesion molecules (CAMs) have been identified. A polyphenol, namely salvianolic acid B from Salvia miltiorrhiza was identified to be a potent antioxidant, endothelial-protecting agent, and an inhibitor to suppress the expression of ICAM and VCAM. This review also briefly describes the strategy for developing herbal medicines as anti-atherosclerotic agents. ? 2008 - IUBMB/IOS Press and the authors. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-69549115198&doi=10.1002%2fbiof.5520340206&partnerID=40&md5=abe0638e2a4990db6e1d7d4c77c1234d https://scholars.lib.ntu.edu.tw/handle/123456789/468542 |
ISSN: | 0951-6433 | DOI: | 10.1002/biof.5520340206 | SDG/關鍵字: | 3 (3,4 dihydroxyphenyl)lactic acid; 4,6 di tert butyl 2,3 dihydro 5 hydroxy 2,2 dipentylbenzofuran; alpha tocopherol; antioxidant; caffeic acid; cell adhesion molecule; cell receptor; copper; Ganoderma lucidum extract; ganodermic acid s; genistein; glabridin; intercellular adhesion molecule 1; lithospermic acid; low density lipoprotein; macrophage scavenger receptor inhibitor; n,n' diphenyl 1,4 phenylenediamine; oxidized low density lipoprotein; probucol; probucol succinate; protein inhibitor; protocatechuic acid; quercetin; resveratrol; rosmarinic acid; salvianolic acid B; scavenger receptor; trolox C; unclassified drug; unindexed drug; vascular cell adhesion molecule 1; antioxidant activity; atherosclerosis; Chinese medicine; drug mechanism; drug structure; endothelial dysfunction; fatty acid oxidation; herbal medicine; human; macrophage; nonhuman; pathogenesis; priority journal; protein expression; protein transport; review; Salvia miltiorrhiza; Animals; Antioxidants; Atherosclerosis; Fusidic Acid; Herbal Medicine; Humans; Lipoproteins, LDL; Plant Extracts; Receptors, Scavenger; Salvia miltiorrhiza; Fabaceae; Lamiaceae; Salvia miltiorrhiza |
顯示於: | 解剖學暨細胞生物學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。