https://scholars.lib.ntu.edu.tw/handle/123456789/468720
標題: | Frequency-specific alternations in the amplitude of low-frequency fluctuations in schizophrenia | 作者: | Yu R. YI-LING CHIEN Wang H.-L.S. CHIH-MIN LIU CHEN-CHUNG LIU TZUNG-JENG HWANG MING-HSIEN HSIEH HAI-GWO HWU WEN-YIH TSENG |
公開日期: | 2014 | 卷: | 35 | 期: | 2 | 起(迄)頁: | 627-637 | 來源出版物: | Human Brain Mapping | 摘要: | Schizophrenia has been associated with abnormal task-related brain activation in sensory and motor regions as well as social cognition network. Recently, two studies investigated temporal correlation between resting-state functional magnetic resonance imaging (R-fMRI) low-frequency oscillations (LFOs) in schizophrenia but reported mixed results. This may be due to the different frequency bands used in these studies. Here we utilized R-fMRI to measure the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) in three different frequency bands (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.08 Hz; and typical band: 0.01-0.08 Hz) in 69 patients with schizophrenia and 62 healthy controls. We showed that there were significant differences in ALFF/fALFF between the two bands (slow-5 and slow-4) in regions including basal ganglia, midbrain, and ventromedial prefrontal cortex. Importantly, we also identified significant interaction between frequency bands and groups in inferior occipital gyrus, precunus, and thalamus. The results suggest that the abnormalities of LFOs in schizophrenia is dependent on the frequency band and suggest that future studies should take the different frequency bands into account when measure intrinsic brain activity. Hum Brain Mapp 35:627-637, 2014. ? 2012 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892458725&doi=10.1002%2fhbm.22203&partnerID=40&md5=a9970dbee49fb9e2f7dc21b7c4e9b4ed https://scholars.lib.ntu.edu.tw/handle/123456789/468720 |
ISSN: | 1065-9471 | DOI: | 10.1002/hbm.22203 | SDG/關鍵字: | adult; article; basal ganglion; brain function; cognition; controlled study; female; functional magnetic resonance imaging; human; low frequency fluctuation; low frequency fraction; low frequency oscillation; major clinical study; male; mesencephalon; occipital gyrus; precuneus; priority journal; resting state network; schizophrenia; signal processing; thalamus; ventromedial prefrontal cortex; basal ganglia; low-frequency fluctuation; MRI; prefrontal cortex; resting state; schizophrenia; Adult; Analysis of Variance; Biological Clocks; Brain; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Oxygen; Psychiatric Status Rating Scales; Rest; Schizophrenia; Young Adult |
顯示於: | 醫療器材與醫學影像研究所 |
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