https://scholars.lib.ntu.edu.tw/handle/123456789/468732
標題: | Stable signatures of schizophrenia in the cortical-subcortical-cerebellar network using fMRI of verbal working memory | 作者: | Matsuo K. Chen S.H.A. CHIH-MIN LIU CHEN-CHUNG LIU TZUNG-JENG HWANG MING-HSIEN HSIEH YI-LING CHIEN Hwu H.-G. WEN-YIH TSENG |
公開日期: | 2013 | 卷: | 151 | 期: | 1月3日 | 起(迄)頁: | 133-140 | 來源出版物: | Schizophrenia Research | 摘要: | A dysfunction in working memory (WM) is a core cognitive impairment in schizophrenia that involves the cortical-subcortical-cerebellar network. We propose that in addition to other often-referred markers, the signal reduction in the network during verbal working memory (VWM) is a stable and intrinsic indicator of illness. We presented a Sternberg VWM task to 46 patients with schizophrenia and 46 healthy controls matched on performance accuracy during functional magnetic resonance imaging (fMRI). Reduced activation was demonstrated in the thalamus, cerebellar vermis, pons and the triangular part of the inferior frontal gyrus (IFG) in the patient group. We also found a "failure of deactivation" in the default mode network (DMN) in patients as represented by a low versus high load VWM. In addition, a reduced left lateralization in the triangular and opercular parts of the IFG was observed in the patient group replicating previous "failure of lateralization" findings in schizophrenia. A comparison of long (10 to 19. years) and short (3 to 9. years) durations of illness (DoIs) demonstrated that the DoI was only associated with the activation changes in the middle frontal gyrus and lateral temporal cortex but not with the IFG-subcortico-cerebellar regions observed. These alterations were consistent with the cognitive dysmetria described in the cortical-subcortical-cerebellar network in schizophrenia. In conclusion, the combination of reduced activation in the cortical-subcortical-cerebellar network during VWM in particular, reduced deactivation in the DMN and reduced lateralization in the IFG is thought to be stable neuroimaging signatures of schizophrenia. ? 2013 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84889083913&doi=10.1016%2fj.schres.2013.10.028&partnerID=40&md5=2c81d0c5056ffba14b2864725a8854e7 https://scholars.lib.ntu.edu.tw/handle/123456789/468732 |
ISSN: | 0920-9964 | DOI: | 10.1016/j.schres.2013.10.028 | SDG/關鍵字: | adult; angular gyrus; article; brain function; cerebellum vermis; clinical article; controlled study; default mode network; disease duration; dysmetria; female; functional magnetic resonance imaging; fusiform gyrus; human; image analysis; image quality; inferior frontal gyrus; inferior temporal gyrus; male; middle aged; middle frontal gyrus; middle temporal gyrus; nuclear magnetic resonance scanner; occipital gyrus; pons; postcentral gyrus; posterior cingulate; prefrontal cortex; priority journal; schizophrenia; task performance; thalamus; verbal memory; working memory; young adult; Cerebellum; Cognitive dysmetria; Default mode network; Left lateralization; Schizophrenia; Verbal working memory; Adult; Brain Mapping; Cerebellum; Cerebral Cortex; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Memory Disorders; Memory, Short-Term; Middle Aged; Neural Pathways; Neuropsychological Tests; Oxygen; Reaction Time; Schizophrenia; Verbal Learning; Young Adult |
顯示於: | 醫療器材與醫學影像研究所 |
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