https://scholars.lib.ntu.edu.tw/handle/123456789/468755
標題: | Neurocognitive improvement after carotid artery stenting in patients with chronic internal carotid artery occlusion and cerebral ischemia | 作者: | MAO-SHIN LIN MING-JANG CHIU YEN-WEN WU CHING-CHANG HUANG CHI-CHAO CHAO YING-HSIEN CHEN HUNG-JU LIN HUNG-YUAN LI YA-FANG CHEN Lin, Lung-Chun YEN BIN LIU CHIA-LUN CHAO WEN-YIH TSENG MING-FONG CHEN HSIEN-LI KAO |
公開日期: | 2011 | 卷: | 42 | 期: | 10 | 起(迄)頁: | 2850-2854 | 來源出版物: | Stroke | 摘要: | Background and Purpose-Chronic cerebral hypoperfusion may lead to impairment in neurocognitive performance in patients with chronic internal carotid artery occlusion, and the effects of carotid artery stenting on neurocognitive function have been unclear. Methods-We prospectively enrolled 20 chronic internal carotid artery occlusion patients with objective ipsilateral hemisphere ischemia, in whom carotid artery stenting was attempted. Functional assessments, including the National Institutes of Health Stroke Scale, Barthel Index, and a battery of neuropsychological tests, including the Mini-Mental State Examination, Alzheimer Disease Assessment Scale-Cognitive Subtest, verbal fluency, and Color Trail Making A and B, were administered before and 3 months after intervention. RESULTS-: Successful recanalization was achieved in 12 of 20 patients (60%). There was no procedural or new cerebral ischemic event, except for 1 intracranial hemorrhage, which occurred during the procedure and had neurologic sequelae; this case was excluded from analysis. The demographics and baseline cognitive performance were similar between the group with a successful outcome (group 1, n=12) and patients who did not (group 2, n=7). Ten of 12 patients in group 1 had improvement in ipsilateral brain perfusion after the procedure, but none in group 2 had improvement. Significant improvement in the scores on the Alzheimer Disease Assessment Scale-Cognitive Subtest (before, 7.7±8.9 versus after, 5.7±7.1; P=0.024), Mini-Mental State Examination (before, 25.8±3.8 versus after, 27.7±2.7; P=0.015), and Color Trail Making A (before, 123.2±68.6 versus after, 99.3±51.5; P=0.017) were found in group 1 but not in group 2. Conclusions-Successful carotid artery stenting improves global cognitive function as well as attention and psychomotor processing speed in patients with chronic internal carotid artery occlusion. ? 2011 American Heart Association, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80053323423&doi=10.1161%2fSTROKEAHA.111.613133&partnerID=40&md5=736f937e204b4e117569f36e60e3380c https://scholars.lib.ntu.edu.tw/handle/123456789/468755 |
ISSN: | 0039-2499 | DOI: | 10.1161/STROKEAHA.111.613133 | SDG/關鍵字: | adult; aged; Alzheimer Disease Assessment Scale; article; attention; Barthel index; brain ischemia; brain perfusion; carotid artery stenting; chronic disease; chronic internal carotid artery occlusion; clinical article; cognition; color trail making a and b; controlled study; female; follow up; human; internal carotid artery occlusion; male; mini mental state examination; National Institutes of Health Stroke Scale; neurologic examination; neuropsychological test; priority journal; psychomotor performance; rating scale; speech articulation; Aged; Brain Ischemia; Carotid Artery, Internal; Carotid Stenosis; Cognition Disorders; Endovascular Procedures; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuropsychological Tests; Stents; Treatment Outcome |
顯示於: | 醫療器材與醫學影像研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。