https://scholars.lib.ntu.edu.tw/handle/123456789/468838
標題: | FGFR1 translocation with concurrent myeloproliferative neoplasm, systemic mastocytosis, and lymphoblastic lymphoma: a case report | 作者: | Chang K. JIA-HAU LIU SHAN-CHI YU CHUNG-WU LIN |
公開日期: | 2018 | 出版社: | W.B. Saunders | 卷: | 74 | 起(迄)頁: | 114-121 | 來源出版物: | Human Pathology | 摘要: | FGFR1 translocation may cause myeloid or lymphoid neoplasm but rarely systemic mastocytosis (SM). Conversely, SM is associated with myeloproliferative neoplasm (MPN) but rarely lymphoblastic lymphoma (LBL) or FGFR1 translocation. We report the first case of FGFR1 translocation in a patient with concurrent LBL, MPN, and SM. A 21-year-old male patient presented with diffuse lymphadenopathies and leukocytosis. TdT + /cytoCD3 + /CD79a weakly+ LBL was identified in the lymph node. Bone marrow had MPN, SM, and TdT + /CD79a + /cytoCD3 weakly+ LBL. The cytogenetic study, reverse-transcription polymerase chain reaction, and sequencing revealed t(8;13)(p11;q12) involving FGFR1 and ZMYM2. Under the hyper–cyclophosphamide, vincristine, doxorubicin, and dexamethasone regimen, complete remission of LBL was achieved despite persistent MPN and SM in the bone marrow. This rare case implies FGFR1 translocation in a precursor cell capable of differentiation into mast cells and lymphoblasts, strengthening the relationship between the 2 tumors in the World Health Organization classification: myeloid and lymphoid neoplasms with FGFR1 abnormalities, and SM with an associated hematologic neoplasm. ? 2017 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044125483&doi=10.1016%2fj.humpath.2017.10.019&partnerID=40&md5=f4d78236b5391a387c9af17a02b1ca51 https://scholars.lib.ntu.edu.tw/handle/123456789/468838 |
ISSN: | 0046-8177 | DOI: | 10.1016/j.humpath.2017.10.019 | SDG/關鍵字: | alpha interferon; cyclophosphamide; cytarabine; dexamethasone; doxorubicin; etoposide; fibroblast growth factor receptor 1; hydroxyurea; mitoxantrone; vincristine; FGFR1 protein, human; fibroblast growth factor receptor 1; adult; Article; bone marrow; bone marrow biopsy; case report; cell differentiation; clinical article; cytogenetics; flow cytometry; follow up; gene; human; human cell; human tissue; leukocytosis; lymph node; lymph node biopsy; lymphadenopathy; lymphoblast; lymphoblastoma; male; mast cell; myeloproliferative neoplasm; peripheral blood stem cell transplantation; remission; reverse transcription polymerase chain reaction; stem cell; systemic mastocytosis; world health organization; young adult; acute lymphoblastic leukemia; gene translocation; genetics; myeloproliferative disorder; pathology; systemic mastocytosis; Humans; Male; Mastocytosis, Systemic; Myeloproliferative Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptor, Fibroblast Growth Factor, Type 1; Translocation, Genetic; Young Adult |
顯示於: | 病理學科所 |
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