https://scholars.lib.ntu.edu.tw/handle/123456789/468849
DC 欄位 | 值 | 語言 |
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dc.contributor.author | YIN-KAI CHEN | en_US |
dc.contributor.author | HSIN-AN HOU | en_US |
dc.contributor.author | JIH-LUH TANG | en_US |
dc.contributor.author | Jhuang J.-Y. | en_US |
dc.contributor.author | Lai Y.-J. | en_US |
dc.contributor.author | Lee M.-C. | en_US |
dc.contributor.author | Kuo Y.-Y. | en_US |
dc.contributor.author | WEN-CHIEN CHOU | en_US |
dc.contributor.author | Liu C.-Y. | en_US |
dc.contributor.author | CHUNG-WU LIN | en_US |
dc.contributor.author | Chuang S.-S. | en_US |
dc.contributor.author | Chen, Chien-Yuan | en_US |
dc.contributor.author | Tseng M.-H. | en_US |
dc.contributor.author | Huang C.-F. | en_US |
dc.contributor.author | Chiang Y.-C. | en_US |
dc.contributor.author | Lee F.-Y. | en_US |
dc.contributor.author | Liu M.-C. | en_US |
dc.contributor.author | Liu C.-W. | en_US |
dc.contributor.author | MING YAO | en_US |
dc.contributor.author | SHANG-YI HUANG | en_US |
dc.contributor.author | BOR-SHENG KO | en_US |
dc.contributor.author | SZU-CHUN HSU | en_US |
dc.contributor.author | SHANG-JU WU | en_US |
dc.contributor.author | WOEI TSAY | en_US |
dc.contributor.author | YAO-CHANG CHEN | en_US |
dc.contributor.author | HWEI-FANG TIEN | en_US |
dc.creator | Chen Y.-K.;Hou H.-A.;Tang J.-L.;Jhuang J.-Y.;Lai Y.-J.;Lee M.-C.;Kuo Y.-Y.;Chou W.-C.;Liu C.-Y.;Chung-Wu Lin;Chuang S.-S.;Chen C.-Y.;Tseng M.-H.;Huang C.-F.;Chiang Y.-C.;Lee F.-Y.;Liu M.-C.;Liu C.-W.;Yao M.;Huang S.-Y.;Ko B.-S.;Hsu S.-C.;Wu S.-J.;Tsay W.;Chen Y.-C.;Tien H.-F. | - |
dc.date.accessioned | 2020-03-03T03:36:42Z | - |
dc.date.available | 2020-03-03T03:36:42Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925843365&doi=10.1371%2fjournal.pone.0119831&partnerID=40&md5=28b4ef253155d82fa2b07e0e980551bc | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/468849 | - |
dc.description.abstract | Background Robo4 is involved in hematopoietic stem/progenitor cell homeostasis and essential for tumor angiogenesis. Expression of Robo4 was recently found in solid tumors and leukemia stem cells. However, the clinical implications of Robo4 expression in patients with acute myeloid leukemia (AML) remain unclear. Methods We investigated the clinical and prognostic relevance of mRNA expression of Robo4 in bone marrow (BM) mononuclear cells from 218 adult patients with de novo AML. We also performed immunohistochemical staining to assess the Robo4 protein expression in the BM biopsy specimens from 30 selected AML patients in the cohort. Results Higher Robo4 expression was closely associated with lower white blood cell counts, expression of HLA-DR, CD13, CD34 and CD56 on leukemia cells, t(8;21) and ASXL1 mutation, but negatively correlated with t(15;17) and CEBPA mutation. Compared to patients with lower Robo4 expression, those with higher expression had significantly shorter dis-ease-free survival (DFS) and overall survival (OS). This result was confirmed in an independent validation cohort. Furthermore, multivariate analyses showed that higher Robo4 expression was an independent poor prognostic factor for DFS and OS in total cohort and patients with intermediate-risk cytogenetics, irrespective of age, WBC count, karyotype, and mutation status of NPM1/FLT3-ITD, and CEBPA. Conclusions BM Robo4 expression can serve as a new biomarker to predict clinical outcomes in AML patients and Robo4 may serve as a potential therapeutic target in patients with higher Robo4 expression. ? 2015 Chen et al. | - |
dc.publisher | Public Library of Science | - |
dc.relation.ispartof | PLoS ONE | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | CCAAT enhancer binding protein alpha; CD34 antigen; CD56 antigen; HLA DR antigen; membrane protein; messenger RNA; microsomal aminopeptidase; roundabout 4 protein; unclassified drug; cell surface receptor; messenger RNA; ROBO4 protein, human; acute granulocytic leukemia; adolescent; adult; age; aged; Article; bone marrow biopsy; bone marrow derived mononuclear cell; cancer prognosis; cancer survival; controlled study; cytogenetics; disease free survival; female; gene expression; human; human cell; immunohistochemistry; karyotype; leukocyte count; major clinical study; male; mutational analysis; overall survival; protein expression; bone marrow; chromosome aberration; genetics; Kaplan Meier method; Leukemia, Myeloid, Acute; metabolism; middle aged; mortality; mutation; pathology; prognosis; remission; treatment outcome; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Bone Marrow; Chromosome Aberrations; Female; Gene Expression; Humans; Kaplan-Meier Estimate; Karyotype; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation; Prognosis; Receptors, Cell Surface; Remission Induction; RNA, Messenger; Treatment Outcome; Young Adult | - |
dc.title | Clinical and prognostic implications of roundabout 4 (Robo4) in adult patients with acute myeloid leukemia | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1371/journal.pone.0119831 | - |
dc.identifier.pmid | 25794001 | - |
dc.identifier.scopus | 2-s2.0-84925843365 | - |
dc.relation.pages | e0119831 | - |
dc.relation.journalvolume | 10 | - |
dc.relation.journalissue | 3 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Hematological Oncology-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-1943-2212 | - |
crisitem.author.orcid | 0000-0003-2780-4845 | - |
crisitem.author.orcid | 0000-0003-4021-3281 | - |
crisitem.author.orcid | 0000-0003-2967-698X | - |
crisitem.author.orcid | 0000-0001-5042-0503 | - |
crisitem.author.orcid | 0000-0003-2831-8822 | - |
crisitem.author.orcid | 0000-0003-2932-0019 | - |
crisitem.author.orcid | 0000-0001-5688-3410 | - |
crisitem.author.orcid | 0000-0002-7965-7579 | - |
crisitem.author.orcid | 0000-0002-0772-869X | - |
crisitem.author.orcid | 0000-0001-6244-3868 | - |
crisitem.author.orcid | 0000-0002-1384-5593 | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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