https://scholars.lib.ntu.edu.tw/handle/123456789/468857
標題: | Detection of the Helicobacter pylori CagA protein in gastric mucosa-associated lymphoid tissue lymphoma cells: Clinical and biological significance | 作者: | SUNG-HSIN KUO Chen L.-T. CHUNG-WU LIN MING-SHIANG WU PING-NING HSU Tsai H.-J. Chu C.-Y. Tzeng Y.-S. HSIU-PO WANG KUN-HUEI YEH ANN-LII CHENG |
公開日期: | 2013 | 卷: | 3 | 期: | 7 | 來源出版物: | Blood Cancer Journal | 摘要: | We previously reported that CagA can be translocated into B cells in Helicobacter pylori (HP) coculture media, and the translocation appears biologically significant as activation of the relevant cellular pathways was noticed. In this study, we further explore if CagA can be detected in malignant B cells of HP-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of CagA was evaluated by immunohistochemistry. CagA expression was further confirmed by western blot analysis. The association between CagA expression in malignant B cells and tumor response to HP eradication therapy (HPE) was evaluated in 64 stage IE gastric MALT lymphoma patients. We detected CagA expression in 31 (48.4%) of 64 patients: 26 (68.4%) of the 38 HP-dependent cases and 5 (19.2%) of the 26 HP-independent cases (P<0.001). Patients with CagA expression responded to HPE quicker than those without (median time to complete remission, 3.0 vs 6.5 months, P=0.025). Our results indicated that CagA can be translocated into malignant B cells of MALT lymphoma, and the translocation is clinically and biologically significant. ? 2013 Macmillan Publishers Limited All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880916132&doi=10.1038%2fbcj.2013.22&partnerID=40&md5=bda1d674b0056a4c655e7ae491ab7d48 https://scholars.lib.ntu.edu.tw/handle/123456789/468857 |
ISSN: | 2044-5385 | DOI: | 10.1038/bcj.2013.22 | SDG/關鍵字: | CagA protein; adult; aged; article; B lymphocyte; cancer patient; cancer regression; controlled study; eradication therapy; female; Helicobacter pylori; human; human cell; human tissue; immunohistochemistry; lymphoma cell; major clinical study; male; marginal zone lymphoma; protein analysis; protein expression; Western blotting |
顯示於: | 病理學科所 |
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