https://scholars.lib.ntu.edu.tw/handle/123456789/468904
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHUNG-WU LIN | en_US |
dc.contributor.author | Liu T.-Y. | en_US |
dc.contributor.author | SHEE-UAN CHEN | en_US |
dc.contributor.author | Wang K.-T. | en_US |
dc.contributor.author | Medeiros L.J. | en_US |
dc.contributor.author | Hsu S.-M. | en_US |
dc.creator | Chung-Wu Lin;Liu T.-Y.;Chen S.-U.;Wang K.-T.;Medeiros L.J.;Hsu S.-M. | - |
dc.date.accessioned | 2020-03-03T03:36:54Z | - |
dc.date.available | 2020-03-03T03:36:54Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-27744506865&doi=10.1182%2fblood-2005-02-0519&partnerID=40&md5=df92695c48f412a2ad52e57258a87952 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/468904 | - |
dc.description.abstract | Most lymphoblastic lymphomas (LBLs) are regarded as neoplasms of immature T cells because they express cytoplasmic CD3 and frequently carry T-cell receptor (TCR) gene rearrangements. Immature natural killer (NK) and T cells, however, have a common bipotent T/NK-cell precursor in the thymus, and NK cells also express cytoplasmic CD3. Thus, some LBLs could arise from immature NK cells. Mature NK cells express 2 CD94 transcripts: 1A, induced by interleukin 15 (IL-15), and 1B constitutively. Because immature NK cells require IL-15 for development, CD94 1A transcripts could be a marker of NK-LBL. To test this hypothesis, we used laser capture microdissection to isolate IL-15 receptor α+ lymphoid cells from the thymus and showed that these cells contained CD94 1A transcripts. We then assessed for CD94 transcripts in 21 cases of LBL that were cytoplasmic CD3+, nuclear terminal deoxynucleotidyl transferase positive (TdT+), and CD56-, consistent with either the T-cell or NK-cell lineage. We found that 7 LBLs expressed CD94 1A transcripts without TCR gene rearrangements, suggesting NK-cell lineage. Patients with NK-LBL were younger than patients with T-LBL (15 years versus 33 years; P = .11) and had a better 2-year survival (100% versus 27%; P < .01). These results improve the current classification of LBL and contribute to our understanding of NK-cell differentiation. ? 2005 by The American Society of Hematology. | - |
dc.relation.ispartof | Blood | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | CD3 antigen; CD56 antigen; cd94 1a antigen; CD94 antigen; cell marker; DNA nucleotidylexotransferase; interleukin 15; interleukin 15 receptor; T lymphocyte receptor; unclassified drug; adolescent; adult; aged; antigen expression; article; cell isolation; cell lineage; cell maturation; comparative study; controlled study; disease classification; female; gene rearrangement; genetic transcription; human; human cell; human tissue; infant; laser capture microdissection; lymphatic leukemia; lymphoblastoma; lymphoid cell; male; natural killer cell; newborn; nucleotide sequence; priority journal; receptor gene; stem cell; thymus | - |
dc.title | CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1182/blood-2005-02-0519 | - |
dc.identifier.pmid | 16046525 | - |
dc.identifier.scopus | 2-s2.0-27744506865 | - |
dc.relation.pages | 3567-3574 | - |
dc.relation.journalvolume | 106 | - |
dc.relation.journalissue | 10 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.orcid | 0000-0001-5042-0503 | - |
crisitem.author.orcid | 0000-0001-7592-3238 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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