https://scholars.lib.ntu.edu.tw/handle/123456789/469749
標題: | The prognostic significance of heart-type fatty acid binding protein in patients with stable coronary heart disease | 作者: | Ho S.-K. YEN-WEN WU Tseng W.-K. Leu H.-B. Yin W.-H. Lin T.-H. Chang K.-C. Wang J.-H. Yeh H.-I. CHAU-CHUNG WU Chen J.-W. |
公開日期: | 2018 | 出版社: | Nature Publishing Group | 卷: | 8 | 期: | 1 | 來源出版物: | Scientific Reports | 摘要: | To investigate the prognostic value of heart-type fatty acid binding protein (H-FABP) in patients with stable coronary heart disease (SCHD). A total of 1,071 patients with SCHD were prospectively enrolled in this Taiwan multicenter registry study, followed for 24 months. The cut-off value of H-FABP, 4.143 pg/mL, was determined using receiver operating characteristic curves. The primary cardiovascular (CV) outcome was composite CV events, defined as cardiovascular or cerebrovascular death, myocardial infarction (MI), stroke, angina related-hospitalization, PAOD-related hospitalization and heart failure. Secondary outcomes included CV or cerebrovascular death, nonfatal MI, nonfatal stroke, and acute heart failure-related hospitalization. We found that the high H-FABP group had more than a two-fold higher rate of primary CV outcomes than the low H-FABP group (32.36% vs. 15.78%, p < 0.001). Eleven patients (4.82%) of the high H-FABP group died during the 24 months of follow-up, compared to only one patient (0.12%) in the low H-FABP group. The acute heart failure-related hospitalization rate was also significantly higher in the high H-FABP group (3.5% vs. 0.95%, p < 0.005). The results remained significant after adjusting for baseline covariates. In conclusion, H-FABP was an independent predictor for CV outcomes in the patients with SCHD, mainly in CV death and acute heart failure-related hospitalization. ? 2018, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054079390&doi=10.1038%2fs41598-018-32210-x&partnerID=40&md5=94e39aafbabef9fbb7fd3c6504e628d1 https://scholars.lib.ntu.edu.tw/handle/123456789/469749 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-018-32210-x | SDG/關鍵字: | fatty acid binding protein 3; adult; blood; clinical trial; coronary artery disease; female; follow up; human; Kaplan Meier method; male; multicenter study; prognosis; prospective study; Taiwan; young adult; Adult; Coronary Disease; Fatty Acid Binding Protein 3; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Prognosis; Prospective Studies; Taiwan; Young Adult |
顯示於: | 醫學教育暨生醫倫理學科所 |
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