https://scholars.lib.ntu.edu.tw/handle/123456789/470174
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yang C.-C. | en_US |
dc.contributor.author | Labaff A. | en_US |
dc.contributor.author | Wei Y. | en_US |
dc.contributor.author | Nie L. | en_US |
dc.contributor.author | Xia W. | en_US |
dc.contributor.author | Huo L. | en_US |
dc.contributor.author | Yamaguchi H. | en_US |
dc.contributor.author | Hsu Y.-H. | en_US |
dc.contributor.author | Hsu J.L. | en_US |
dc.contributor.author | Liu D. | en_US |
dc.contributor.author | Lang J. | en_US |
dc.contributor.author | Du Y. | en_US |
dc.contributor.author | HUANG-CHUN LIEN | en_US |
dc.contributor.author | Li L.-Y. | en_US |
dc.contributor.author | Deng R. | en_US |
dc.contributor.author | Chan L.-C. | en_US |
dc.contributor.author | Yao J. | en_US |
dc.contributor.author | Kleer C.G. | en_US |
dc.contributor.author | Hortobagyi G.N. | en_US |
dc.contributor.author | Hung M.-C. | en_US |
dc.creator | Yang C.-C.;Labaff A.;Wei Y.;Nie L.;Xia W.;Huo L.;Yamaguchi H.;Hsu Y.-H.;Hsu J.L.;Liu D.;Lang J.;Du Y.;Huang-Chun Lien;Li L.-Y.;Deng R.;Chan L.-C.;Yao J.;Kleer C.G.;Hortobagyi G.N.;Hung M.-C. | - |
dc.date.accessioned | 2020-03-05T05:51:17Z | - |
dc.date.available | 2020-03-05T05:51:17Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1943-8141 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84939503541&partnerID=40&md5=d73f4c30cd6b04020f0b6c9815b4ec41 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/470174 | - |
dc.description.abstract | Triple-negative breast cancer (TNBC), which is closely related to basal-like breast cancer, is a highly aggressive subtype of breast cancer that initially responds to chemotherapy but eventually develops resistance. This presents a major clinical challenge as there are currently no effective targeted therapies available due to its lack of HER2 and estrogen receptor expression. Here, we show that cyclin E and the enhancer of zeste 2 (EZH2) are closely co-expressed in TNBC patients, and cyclin E/CDK2 phosphorylates EZH2 at T416 (pT416-EZH2) in vivo. Phosphorylation of EZH2 at T416 enhances the ability of EZH2 to promote TNBC cell migration/invasion, tumorsphere formation, and in vivo tumor growth. In addition, high pT416-EZH2 correlates with poorer survival in TNBC patients. These findings suggest that pT416 has the potential to serve as a therapeutic biomarker for the aggressive forms of breast cancer and provide a rationale for the use of CDK2 inhibitors to treat TNBC. ? 2015 E-Century Publishing Corporation. All rights reserved. | - |
dc.publisher | E-Century Publishing Corporation | - |
dc.relation.ispartof | American Journal of Translational Research | - |
dc.subject | CDK2; EZH2; Phosphorylation | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | actin; cyclin dependent kinase 2; cyclin E; methionine; n [5 (5 tert butyl 2 oxazolylmethylthio) 2 thiazolyl] isonipecotamide; nucleophosmin; phospho nucleophosmin; roscovitine; transcription factor EZH2; tubulin; unclassified drug; animal experiment; animal model; animal tissue; Article; autoradiography; carcinogenesis; cell growth; cell invasion; cell migration; controlled study; female; human; human cell; IC50; immunoblotting; immunohistochemistry; immunoprecipitation; mouse; MTT assay; nonhuman; protein phosphorylation; triple negative breast cancer; tumor growth; tumor sphere formation assay | - |
dc.title | Phosphorylation of ezh2 at t416 by cdk2 contributes to the malignancy of triple negative breast cancers | en_US |
dc.type | journal article | en |
dc.identifier.scopus | 2-s2.0-84939503541 | - |
dc.relation.pages | 1009-1020 | - |
dc.relation.journalvolume | 7 | - |
dc.relation.journalissue | 6 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.orcid | 0000-0003-1472-1231 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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