https://scholars.lib.ntu.edu.tw/handle/123456789/470922
標題: | The relationship among carotid artery remodeling, cardiac geometry, and serum N-terminal Pro-B-Type natriuretic peptide level in asymptomatic Asians: Sex-differences and longitudinal GEE study | 作者: | Chien C.-Y. Liu C.-C. Po H.L. Yen C.-H. Hou C.J.-Y. Kuo J.-Y. Hung C.-L. SHOEI-SHEN WANG Yeh H.-I. Lam C.S.P. |
公開日期: | 2015 | 出版社: | Public Library of Science | 卷: | 10 | 期: | 7 | 來源出版物: | PLoS ONE | 摘要: | Background Carotid artery remodeling is known to be associated with a variety of cardiovascular diseases. However, there is limited information regarding gender differences in carotid remodeling. We sought to investigate the associations among blood pressure (BP), carotid artery remodeling and cardiac geometries, and further explore gender differences. Materials and Methods In a large cohort of asymptomatic adults undergoing routine health screening with repeated observations, we related measures of carotid artery diameter (CCAD) to various BP components, cardiac geometries and blood N-terminal pro-brain natriuretic peptide (NT-proBNP) level, both from baseline cross-sectional and longitudinal dataset using generalized estimating equations (GEE). Results A total of 2,914 person-visits (baseline: n=998, mean age: 47 ± 8.9 years, 34% female) were studied (median: 6 ± 1.73 years follow up). We observed that CCAD was larger in men (p<0.01) and positively related to baseline age or all blood pressure components (including systolic BP [SBP], diastolic BP [DBP] and pulse pressure [PP], all p<0.01) even after accounting for clinical covariates, which did not change significantly at follow up (repeat-visit longitudinal GEE models). At baseline, per each increased unit of CCAD was associated with elevated LV mass index (β-coef: 6.72, with odds ratio [OR]: 1.47, 95% CI: 1.06 to 2.07 for ventricular hypertrophy; AUROC: 0.65, CCAD cut-off: 7.25mm) and NT-proBNP (β-coef: 5.35, OR: 4.22, 95% CI: 1.42 to 12.6 for >=300pg/mL; AUROC: 0.79, CCAD cut-off: 7.95mm, all p<0.05), which remained significant in multi-variate and longitudinal models. There was a prominent sex interaction (p for interaction with age and systolic BP: 0.004 and 0.028 respectively), where the longitudinal associations of age and systolic BP with increasing CCAD as more pronounced in women than men. Conclusion These data demonstrated that carotid artery remodeling may parallel subclinical biomarker of cardiac dysfunction, and further showed greater effects of aging and higher blood pressure on such remodeling process in women than men. Further study is warranted to understand how this predisposition of elderly hypertensive women to vascular remodeling may play a role in clinical settings. ? 2015 Chien et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940977603&doi=10.1371%2fjournal.pone.0131440&partnerID=40&md5=6993b5d42a632095f54104403897f571 https://scholars.lib.ntu.edu.tw/handle/123456789/470922 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0131440 | SDG/關鍵字: | amino terminal pro brain natriuretic peptide; biological marker; brain natriuretic peptide; peptide fragment; pro-brain natriuretic peptide (1-76); adult; artery diameter; Article; Asian; blood sampling; carotid artery; carotid artery remodeling; cohort analysis; controlled study; diastolic blood pressure; Doppler echocardiography; female; geometry; heart left ventricle mass; heart ventricle hypertrophy; human; longitudinal study; major clinical study; male; mass screening; protein determination; sex difference; systolic blood pressure; transthoracic echocardiography; vascular remodeling; age; Asian continental ancestry group; asymptomatic disease; blood; blood pressure; cardiac muscle; carotid artery; cross-sectional study; echocardiography; heart; heart disease; heart rate; middle aged; pathology; pathophysiology; physiology; sexual development; Taiwan; Age Factors; Asian Continental Ancestry Group; Asymptomatic Diseases; Biomarkers; Blood Pressure; Carotid Arteries; Cross-Sectional Studies; Echocardiography; Female; Heart; Heart Diseases; Heart Rate; Humans; Longitudinal Studies; Male; Middle Aged; Myocardium; Natriuretic Peptide, Brain; Peptide Fragments; Sex Characteristics; Taiwan; Vascular Remodeling |
顯示於: | 醫學系 |
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