https://scholars.lib.ntu.edu.tw/handle/123456789/470974
標題: | Relationship between Bone Mineral Density and Serum Osteoprotegerin in Patients with Chronic Heart Failure | 作者: | YING-HSIEN CHEN YEN-WEN WU WEI-SHIUNG YANG SHOEI-SHEN WANG CHII-MING LEE NAI-KUAN CHOU RON-BIN HSU YEN-HUNG LIN MAO-SHIN LIN YI-LWUN HO MING-FONG CHEN |
公開日期: | 2012 | 卷: | 7 | 期: | 8 | 來源出版物: | PLoS ONE | 摘要: | Purpose: Heart failure (HF) had been reported with increased risk of hip fractures. However, the relationship between circulating biomarkers and bone mineral density (BMD) in chronic HF remained unclear. Methods: This is a cross-sectional study which recruited stable chronic HF from registry of the Heart Failure Center of National Taiwan University Hospital. Patients underwent dual-energy x-ray absorptiometry (DEXA) measurements at hip and lumbar spines and biochemical assessments including B-type natriuretic peptide (BNP-32), myostatin, follistatin and osteoprotegerin (OPG). Results: A total of 115 stable chronic HF individuals with left ventricular ejection fraction (EF) &45% (74% of male, mean age at 59) were recruited with 24 patients in NYHA class I, 73 patients in NYHA class II and 18 patients in NYHA class III. Results of BMD showed that Z scores of hip in NYHA III group (-0.12±1.15) was significantly lower than who were NYHA II (0.58±1.04). Serum OPG was significantly higher in subjects of NYHA III (9.3±4.6 pmol/l) than NYHA II (7.4±2.8 pmol/l) or NYHA I (6.8±3.6 pmol/l) groups. There's a significant negative association between log transformed serum OPG and trochanteric BMD (R = -0.299, P = 0.001), which remained significant after multivariate analysis. Conclusions: Our study demonstrated an inverse association between serum OPG and trochanteric BMD in patients with HF. OPG may be a predictor of BMD and an alternative to DEXA for identifying at risk HF patients for osteoporosis. ? 2012 Chen et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865608507&doi=10.1371%2fjournal.pone.0044242&partnerID=40&md5=25e5b7947f04841dc49d79d6a54bf999 https://scholars.lib.ntu.edu.tw/handle/123456789/470974 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0044242 | SDG/關鍵字: | brain natriuretic peptide; follistatin; myostatin; osteoprotegerin; adult; age distribution; article; bone density; controlled study; cross-sectional study; disease association; disease classification; disease registry; disease severity; dual energy X ray absorptiometry; female; gender; heart failure; heart left ventricle ejection fraction; hip; human; human tissue; lumbar spine; major clinical study; male; osteoporosis; predictive value; protein blood level; protein determination; protein expression; risk assessment; Absorptiometry, Photon; Adult; Aged; Biological Markers; Bone Density; Chronic Disease; Cross-Sectional Studies; Female; Femur; Heart Failure; Humans; Lumbar Vertebrae; Male; Middle Aged; Multivariate Analysis; Osteoporosis; Osteoprotegerin |
顯示於: | 醫學系 |
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