https://scholars.lib.ntu.edu.tw/handle/123456789/473423
Title: | Prognostic significance of insulin-like growth factor II mRNA-binding protein 3 expression in gastric adenocarcinoma | Authors: | YUNG-MING JENG Wang T.-H. Lu S.-H. RAY-HWANG YUAN Hsu H.-C. |
Issue Date: | 2009 | Journal Volume: | 96 | Journal Issue: | 1 | Start page/Pages: | 66-73 | Source: | British Journal of Surgery | Abstract: | Background: Insulin-like growth factor II mRNA-binding protein (IMP) 3 is expressed in embryonic tissues and multiple cancers. The aim was to establish the prognostic value of IMP-3 expression in gastric adenocarcinoma. Methods: IMP-3 expression in resected gastric adenocarcinomaswas analysed by immunohistochemistry. Results: IMP-3 was expressed in 183 (58.1 per cent) of 315 tumours. Expression was associated with older age (P < 0.001), larger tumour size (P = 0.009), deep tumour invasion (P < 0.001) and lymph node metastasis (P < 0.001). IMP-3-positive tumours were associated with poorer 5-year survival than negative tumours at all stages (stage I, 82 versus 97 per cent; stage II, 55 versus 78 per cent; stage III and IV, 11 versus 25 per cent; P = 0.005, P = 0.033 and P = 0.036 respectively). Multivariable analysis identified IMP-3 (hazard ratio (HR) 1.93), depth of tumour invasion (HR 3.69, 9.77 and 10.69 for pathological tumour stage (pT) 2, pT3 and pT4 respectively versus pT1), and lymph node metastasis (HR 1.57, 3.29 and 3.40 for pathological node stage (pN) 1, pN2 and pN3 respectively versus pN0) as independent prognostic factors. Conclusion: IMP-3 expression correlates with the metastatic potential of gastric adenocarcinoma and is an independent prognostic factor. Copyright ? 2008 British Journal of Surgery Society Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149522205&doi=10.1002%2fbjs.6438&partnerID=40&md5=578191a27d58999f9ccd626d0caa048d https://scholars.lib.ntu.edu.tw/handle/123456789/473423 |
ISSN: | 0007-1323 | DOI: | 10.1002/bjs.6438 | SDG/Keyword: | Adenocarcinoma; Adult; Aged; Aged, 80 and over; Female; Humans; Immunohistochemistry; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Protein 3; Kaplan-Meiers Estimate; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Risk Factors; RNA, Messenger; Stomach Neoplasms |
Appears in Collections: | 病理學科所 |
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