https://scholars.lib.ntu.edu.tw/handle/123456789/473462
標題: | Unexpected rapid progression of metastatic adenoid cystic carcinoma during treatment with imatinib mesylate | 作者: | CHING-HUNG LIN RUOH-FANG YEN YUNG-MING JENG Tzen C.-Y. CHIUN HSU RUEY-LONG HONG |
公開日期: | 2005 | 卷: | 27 | 期: | 12 | 起(迄)頁: | 1022-1027 | 來源出版物: | Head and Neck | 摘要: | Background. There is a lack of effective treatment for metastatic adenoid cystic carcinoma (ACC), a usually indolent tumor. We studied the efficacy of imatinib mesylate, a potent inhibitor of KIT tyrosine kinase, in patients with KIT-positive metastatic ACC. Methods. Five patients with lung metastasis were treated in a pilot study with imatinib 400 mg by mouth twice a day. Mutations of c-kit and platelet-derived growth factor receptor (PDGFR)-α in tumors from these patients were analyzed. Results. Disease progression was noted in three of five patients during the short treatment periods, ranging from 2 to 3 weeks. Three patients died of disease within 6 months. No detectable mutations were found in c-kit and PDGFR-α. Conclusion. We observed an unexpected high progression rate of metastatic ACC within short periods during imatinib treatment. Use of imatinib to treat cancers without c-kit or PDGFR-α mutation should be approached with caution. ? 2005 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-28244448498&doi=10.1002%2fhed.20274&partnerID=40&md5=18e32c6cf2678c2f19926551611fe9f0 https://scholars.lib.ntu.edu.tw/handle/123456789/473462 |
ISSN: | 1043-3074 | DOI: | 10.1002/hed.20274 | SDG/關鍵字: | alanine aminotransferase; aspartate aminotransferase; cisplatin; DNA; fluorodeoxyglucose f 18; ifosfamide; imatinib; paclitaxel; platelet derived growth factor receptor; protein tyrosine kinase inhibitor; stem cell factor receptor; adenoid cystic carcinoma; adult; anemia; anorexia; article; bone metastasis; brain metastasis; cancer growth; clinical article; computer assisted tomography; controlled study; diarrhea; dizziness; drug efficacy; drug mechanism; edema; fatigue; female; human; human tissue; liver toxicity; lung metastasis; male; nausea; nuclear magnetic resonance imaging; pilot study; pleura effusion; pleura metastasis; polymerase chain reaction; positron emission tomography; priority journal; rash; thorax radiography; thrombocytopenia; tumor growth; tumor volume; vomiting; Administration, Oral; Adult; Antineoplastic Agents; Carcinoma, Adenoid Cystic; Disease Progression; DNA Mutational Analysis; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Pilot Projects; Piperazines; Pleural Effusion, Malignant; Protein-Tyrosine Kinases; Pyrimidines |
顯示於: | 病理學科所 |
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