https://scholars.lib.ntu.edu.tw/handle/123456789/473497
標題: | Clinicopathological and molecular biological features of colorectal cancer in patients less than 40 years of age | 作者: | JIN-TUNG LIANG KUO-CHIN HUANG ANN-LII CHENG YUNG-MING JENG MING-SHIANG WU Wang S.M. |
公開日期: | 2003 | 卷: | 90 | 期: | 2 | 起(迄)頁: | 205-214 | 來源出版物: | British Journal of Surgery | 摘要: | Background: The aim of the present study was to identify the clinicopathological and molecular biological characteristics of early-onset colorectal cancers. Methods: The clinicopathological and molecular biological parameters of 138 consecutive patients with colorectal cancer aged less than 40 years were compared with those of 339 patients aged 60 years or more. Results: The younger patients with colorectal cancer had more mucin-producing (14.5 versus 4.7 per cent; P < 0.001) and poorly differentiated (7.2 versus 3.3 per cent; P = 0.015) tumours, a higher incidence of synchronous (5.8 versus 1.2 per cent; P = 0.007) and metachronous (4.0 versus 0.6 per cent; P = 0.023) colorectal cancers, and more advanced tumour stage (P < 0.001) than older patients. The operative mortality rate was lower (0.7 versus 5.0 per cent; P = 0.026), and cancer-specific survival was similar (in stage I, II and III disease; P > 0.05) or better (in stage IV disease; 95 per cent confidence interval 22.50 to 28.41 versus 12.61 to 17.05 months; P < 0.001). There was a higher percentage of normal p53 expression (61.1 versus 46.8 per cent; P = 0.023) and high-frequency microsatellite instability (MSI-H) (29.4 versus 6.3 per cent; P < 0.001), and a similar family history of cancer (17.5 versus 14.2 per cent; P > 0.05), compared with older patients. Conclusion: Young patients with colorectal cancer have several distinct clinicopathological and molecular biological features. The mechanisms underlying the inconsistency between the presence of MSI-H and a family history of cancer in these early-onset colorectal cancers deserve further investigation. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037329222&doi=10.1002%2fbjs.4015&partnerID=40&md5=ff6163ac595263a719a3314b45729c5c https://scholars.lib.ntu.edu.tw/handle/123456789/473497 |
ISSN: | 0007-1323 | DOI: | 10.1002/bjs.4015 | SDG/關鍵字: | mucin; protein p53; adolescent; adult; age distribution; article; cancer classification; cancer staging; cancer survival; colorectal carcinoma; confidence interval; controlled study; family history; female; human; human tissue; major clinical study; male; microsatellite instability; molecular biology; onset age; priority journal; protein expression; surgical mortality; survival rate; treatment outcome; tumor differentiation; tumor localization; tumor volume; Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Female; Fluorouracil; Genes, DCC; Genes, p53; Genes, ras; Humans; Male; Microsatellite Repeats; Middle Aged; Neoplasm Staging; Pedigree; Polymerase Chain Reaction |
顯示於: | 病理學科所 |
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