https://scholars.lib.ntu.edu.tw/handle/123456789/473605
標題: | Molecular pathology of Müller's muscle in Graves' ophthalmopathy | 作者: | Shih M.-J. SHU-LANG LIAO KUAN-TING KUO Smith T.J. LEE-MING CHUANG |
公開日期: | 2006 | 卷: | 91 | 期: | 3 | 起(迄)頁: | 1159-1167 | 來源出版物: | Journal of Clinical Endocrinology and Metabolism | 摘要: | Context: Upper lid retraction is a common sign in Graves' ophthalmopathy (GO). Whether M?ller's muscle is involved in upper lid retraction has not been fully elucidated. Objective: The objective of the study was to understand the molecular pathology of M?ller's muscle in GO. Design/Setting/ Participants: A method for measurement of histological changes was developed and used to correlate severity and expression of cell-specific genes in GO. Main Outcome Measures: Histological changes, clinical severity of upper lid retraction, and mRNA expression in M?ller's muscle in GO were measured. Results: The degree of fibrosis correlates with severity of upper lid retraction. Macrophage infiltration was increased in fibrotic areas, consistent with higher levels of macrophage-colony stimulating factor mRNA. Levels of peroxisome proliferator-activated receptor-γ mRNA were up-regulated and correlated with fat infiltration. Decreased muscle mass correlated with lower myocardin mRNA expression. The expression of c-kit levels was decreased in diseased muscles, consistent with diminished mast cell numbers. Conclusion: The pathological changes of M?ller's muscle correlate with clinical severity of upper lid retraction in GO. Patterns of gene expression appear to correlate with the histopathological changes in this disease process. Copyright ? 2006 by The Endocrine Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644819372&doi=10.1210%2fjc.2005-1877&partnerID=40&md5=18287ea804dfe6c587ad3d9a190b94ac https://scholars.lib.ntu.edu.tw/handle/123456789/473605 |
ISSN: | 0021-972X | DOI: | 10.1210/jc.2005-1877 | SDG/關鍵字: | colony stimulating factor 1; messenger RNA; myocardin; peroxisome proliferator activated receptor gamma; stem cell factor; messenger RNA; RNA; adult; article; cell count; cell infiltration; cell specificity; clinical article; controlled study; disease severity; endocrine ophthalmopathy; eyelid retraction; female; gene expression; histopathology; human; human tissue; macrophage; male; mast cell; Mueller cell; muscle mass; ocular fibrosis; priority journal; receptor upregulation; upper eyelid; endocrine ophthalmopathy; extraocular muscle; eyelid; gene expression regulation; genetics; isolation and purification; middle aged; pathology; reverse transcription polymerase chain reaction; Adult; Eyelids; Female; Gene Expression Regulation; Graves Ophthalmopathy; Humans; Male; Middle Aged; Oculomotor Muscles; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger |
顯示於: | 病理學科所 |
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