https://scholars.lib.ntu.edu.tw/handle/123456789/473606
標題: | Comparison of the expression and prognostic significance of differentiation markers between diffuse large B-cell lymphoma of central nervous system origin and peripheral nodal origin | 作者: | CHING-HUNG LIN KUAN-TING KUO Chuang S.-S. SUNG-HSIN KUO Chang J.H. Chang K.-C. Hsu H.-C. HWEI-FANG TIEN ANN-LII CHENG |
公開日期: | 2006 | 卷: | 12 | 期: | 4 | 起(迄)頁: | 1152-1156 | 來源出版物: | Clinical Cancer Research | 摘要: | Purpose: Whether diffuse large B-cell lymphoma (DLBCL) of primary central nervous system origin (PCNSL) is biologically different from DLBCL of peripheral nodal origin (NL) remains unclear. The purpose of this study was to compare the expression frequencies and prognostic significance of a panel of cell differentiation markers between these two disease entities. Experimental Design: This study included HIV-unrelated patients with PCNSL (n = 51) and NL (n = 72) treated at four hospitals in Taiwan for whom archival tumor tissue was available. Immunohistochemistry for CD10, BCL-6, MUM-1, vs38c, CD138, and BCL-2 was done. CD10, BCL-6, and MUM-1 expression results were used to classify all cases into the germinal center B-cell (GCB) or the non-GCB subgroup. The prognostic significances of clinical and immunophenotypic markers were evaluated. Results: Nuclear MUM-1 expression was significantly higher in PCNSL than in NL (P < 0.001; 84% versus 53%). PCNSL tumors were more frequently classified into the non-GCB subgroup than NL tumors (P = 0.020; 78% versus 62%). For patients with PCNSL, univariate analysis showed that patients with BCL-6 expression had a trend towards longer survival (P = 0.073; median survival, 25.3 versus 7.3 months), and multivariate analysis showed BCL-6 was an independent prognostic factor (P = 0.026). For patients with NL, both of univariate (P = 0.003) and multivariate analyses (P = 0.002) showed that GCB was significantly associated with favorable survival. Conclusion: The higher frequency of non-GCB subclassification, which was mainly contributed by nuclear MUM-1 expression in PCNSL implies that it has a more differentiated cellular origin than NL. BCL-6 expression in patients with PCNSL and GCB subgroup in patients with NL were favorable prognostic factors. ? 2006 American Association for Cancer Research. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644757808&doi=10.1158%2f1078-0432.CCR-05-1699&partnerID=40&md5=3ecbfe73a511a536c4d4d731b62e68f3 https://scholars.lib.ntu.edu.tw/handle/123456789/473606 |
ISSN: | 1078-0432 | DOI: | 10.1158/1078-0432.CCR-05-1699 | SDG/關鍵字: | common acute lymphoblastic leukemia antigen; cyclophosphamide; doxorubicin; epirubicin; methotrexate; mitoxantrone; prednisone; protein bcl 2; protein bcl 6; protein mum 1; protein vs83c; syndecan 1; tumor marker; unclassified drug; vincristine; adolescent; adult; aged; article; B cell lymphoma; cell differentiation; cell nucleus; controlled study; diffuse large B cell lymphoma; female; germinal center; human; human tissue; immunohistochemistry; immunophenotyping; large cell lymphoma; male; multivariate analysis; primary central nervous system lymphoma; priority journal; prognosis; protein expression; survival time; Taiwan; Antibodies, Monoclonal; Antigens, Differentiation; B-Lymphocytes; Biological Markers; Central Nervous System; DNA-Binding Proteins; Female; Germinal Center; Humans; Immunohistochemistry; Interferon Regulatory Factors; Lymph Nodes; Lymphoma, Large-Cell, Diffuse; Male; Membrane Glycoproteins; Middle Aged; Neprilysin; Prognosis; Proteoglycans; Proto-Oncogene Proteins c-bcl-2; Survival Analysis; Syndecan-1; Syndecans |
顯示於: | 病理學科所 |
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