https://scholars.lib.ntu.edu.tw/handle/123456789/473651
標題: | Primary effusion lymphoma involving both pleural and abdominal cavities in a patient with hepatitis B virus-related liver cirrhosis | 作者: | Hsieh P.-Y. Huang S.-I. Li D.-K. TSUI-LIEN MAO JIN-CHUAN SHEU CHIEN-HUNG CHEN |
公開日期: | 2007 | 出版社: | Scientific Communications International Ltd | 卷: | 106 | 期: | 6 | 起(迄)頁: | 504-508 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Primary effusion lymphoma (PEL) is an unusual form of non-Hodgkin's lymphoma, which is characterized by lymphomatous effusion in body cavities, but no associated mass lesions. It is usually associated with an immunodeficient state most often with the human immunodeficiency virus (HIV). We describe a 54-year-old man with HIV-negative PEL, with a history of hepatitis B virus-related liver cirrhosis. Both abdominal and pleural cavities were involved; no solid tumor masses were found and bone marrow investigations were normal. The ascites and pleural effusion contained numerous pleomorphic lymphoid cells. Immunophenotyping was positive for CD138. Chromosome study showed complex cytogenetics. The genomic human herpesvirus-8 was detected in the lymphoma cells. It is postulated that the immunosuppressed state in this patient may have been caused by cirrhosis. The patient received four cycles of chemotherapy of CHOP and Picibanil (OK-432) intraperitoneal administration. However, no durable remission was achieved. Adefovir failed to halt the progressive liver failure after the development of YMDD mutant related to lamivudine. He died of sepsis and hepatic failure. ? 2007 Elsevier & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34447340214&doi=10.1016%2fS0929-6646%2809%2960302-8&partnerID=40&md5=bc91573204ad6d278503475d6e8d2ac6 https://scholars.lib.ntu.edu.tw/handle/123456789/473651 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(09)60302-8 | SDG/關鍵字: | adefovir; alanine aminotransferase; antibiotic agent; bilirubin; creatinine; cyclophosphamide; doxorubicin; granulocyte colony stimulating factor; hepatitis B antigen; hepatitis C antigen; lactate dehydrogenase; lamivudine; picibanil; prednisolone; vincristine; abdominal distension; adult; alanine aminotransferase blood level; article; ascites; bacterial peritonitis; bilirubin blood level; biochemistry; case report; clinical assessment; clinical feature; computer assisted tomography; creatinine blood level; cytogenetics; cytology; drug withdrawal; echography; febrile neutropenia; follow up; hepatic encephalopathy; hepatitis B; Hepatitis B virus; hepatorenal syndrome; human; human cell; human tissue; hypoalbuminemia; immunohistochemistry; immunophenotyping; kidney disease; lactate dehydrogenase blood level; liver cirrhosis; liver failure; liver function; male; mortality; normochromic normocytic anemia; nuclear magnetic resonance imaging; peritoneal cavity; pleura cavity; polymerase chain reaction; primary effusion lymphoma; prothrombin time; sepsis; splenomegaly; treatment outcome |
顯示於: | 病理學科所 |
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