https://scholars.lib.ntu.edu.tw/handle/123456789/473661
標題: | Pure-type clear cell carcinoma of the ovary as a distinct histological type and improved survival in patients treated with paclitaxel-platinum-based chemotherapy in pure-type advanced disease | 作者: | Ho C.-M. RUBY YUN-JU HUANG Chen T.-C. Huang S.-H. Liu F.-S. Chang Chien C.-C. Yu M.-H. TSUI-LIEN MAO Wang T.-Y. CHANG-YAO HSIEH |
公開日期: | 2004 | 卷: | 94 | 期: | 1 | 起(迄)頁: | 197-203 | 來源出版物: | Gynecologic Oncology | 摘要: | Objective. The aim was to compare survival in pure and mixed-type advanced clear cell ovarian carcinoma and to determine the benefits among patients with pure advanced clear cell ovarian carcinoma treated in paclitaxel-platinum-based chemotherapy in comparison with those treated in conventional platinum-based chemotherapy after primary surgery. Methods. Between 1994 and 2001, 31 women with stage III and IV pure clear cell ovarian carcinoma and nine patients with stage III and IV mixed-type clear cell carcinoma were identified from the tumor registry of six institutions. All patients underwent cytoreductive surgery followed by conventional platinum-based chemotherapy or paclitaxel and platinum-based chemotherapy. Results. The median survival of women with pure clear cell carcinoma was 11 months, compared to 48+ months for those with mixed-type clear cell carcinoma (P = 0.003). Overall, for women with pure clear cell carcinoma, 35% had clinically complete responses to chemotherapy. For women with pure clear cell carcinoma treated with paclitaxel-platinum-based chemotherapy, the median survival was significantly longer than for those treated with conventional platinum-based chemotherapy (16.26 vs. 10.75 months, P = 0.045; with optimal cytoreduction, 40.95 vs. 9.02 months, P = 0.028). Univariate analysis showed paclitaxel-platinum-based treatment was the only favorable prognostic factor for women with advanced pure clear cell ovarian carcinoma (P = 0.05). Conclusions. Patients with advanced pure clear cell ovarian carcinoma have poorer prognoses than those with the mixed type. Paclitaxel-platinum-based chemotherapy improved survival among our patients with advanced pure clear cell carcinoma, especially for those with optimal cytoreduction. ? 2004 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-3242725237&doi=10.1016%2fj.ygyno.2004.04.004&partnerID=40&md5=819317a26639a9427f97a3a6982b0924 https://scholars.lib.ntu.edu.tw/handle/123456789/473661 |
ISSN: | 0090-8258 | DOI: | 10.1016/j.ygyno.2004.04.004 | SDG/關鍵字: | carboplatin; cisplatin; cyclophosphamide; paclitaxel; platinum derivative; adult; aged; article; cancer chemotherapy; cancer registry; cancer staging; cancer survival; clear cell carcinoma; clinical article; clinical trial; controlled clinical trial; controlled study; female; human; ovary carcinoma; priority journal; prognosis; Adenocarcinoma, Clear Cell; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Humans; Middle Aged; Ovarian Neoplasms; Paclitaxel; Survival Rate |
顯示於: | 病理學科所 |
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