https://scholars.lib.ntu.edu.tw/handle/123456789/473677
標題: | What is new about the molecular genetics in matrix-producing soft tissue tumors? -The contributions to pathogenetic understanding and diagnostic classification | 作者: | Kao Y.-C. JEN-CHIEH LEE Huang H.-Y. |
關鍵字: | Diagnosis; Genetics; Matrix; Soft tissue; Tumor | 公開日期: | 2020 | 出版社: | Springer | 卷: | 476 | 期: | 1 | 起(迄)頁: | 121-134 | 來源出版物: | Virchows Archiv | 摘要: | Soft tissue tumors encompass a wide variety of mesenchymal neoplasms exhibiting diverse clinical, pathologic, and molecular features. Among these, osteoid and/or chondroid matrix deposition in some soft tissue tumors represents a noticeable characteristic. Unlike matrices present in bone tumors where they likely reveal the respective cells of origin (i.e., osteoblastic or chondroblastic precursors), those existing in soft tissue tumors more often denote a metaplastic phenomenon and reflect the diversity of differentiation these tumors can display. While many soft tissue tumor types can occasionally harbor metaplastic bone or cartilage as an incidental component or heterologous differentiation, in some other tumor types, the production of these matrices is a frequent and distinctive, if not diagnostic, feature. This review focuses on the latter tumor types where emerging immunohistochemical and molecular evidence has significantly improved our understanding of their respective pathogenesis and histopathological spectra. These tumor types include ossifying fibromyxoid tumor, phosphaturic mesenchymal tumor, synovial chondromatosis, soft tissue chondroma, calcifying aponeurotic fibroma, giant cell tumor of soft tissue, myositis ossificans and related diseases, mesenchymal chondrosarcoma, and extraskeletal osteosarcoma. ? 2019, Springer-Verlag GmbH Germany, part of Springer Nature. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074758693&doi=10.1007%2fs00428-019-02679-6&partnerID=40&md5=2ffb5aeba2caeb1e20cac7b1541b3e20 https://scholars.lib.ntu.edu.tw/handle/123456789/473677 |
ISSN: | 0945-6317 | DOI: | 10.1007/s00428-019-02679-6 | SDG/關鍵字: | calcifying aponeurotic fibroma; chondroma; chondromatosis; chondrosarcoma; extraskeletal osteosarcoma; giant cell tumor; human; mesenchymal chondrosarcoma; molecular genetics; ossifying fibromyxoid tumor; ossifying myositis; osteosarcoma; phosphaturic mesenchymal tumor; priority journal; Review; soft tissue chondroma; soft tissue tumor; genetics; immunohistochemistry; pathology; soft tissue tumor; MDM2 protein, human; protein MDM2; Chondromatosis, Synovial; Giant Cell Tumors; Humans; Immunohistochemistry; Myositis Ossificans; Osteosarcoma; Proto-Oncogene Proteins c-mdm2; Soft Tissue Neoplasms |
顯示於: | 病理學科所 |
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