https://scholars.lib.ntu.edu.tw/handle/123456789/473712
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JEN-CHIEH LEE | en_US |
dc.contributor.author | Fletcher C.D.M. | en_US |
dc.creator | Jen-Chieh Lee ;Fletcher C.D.M. | - |
dc.date.accessioned | 2020-03-07T06:52:16Z | - |
dc.date.available | 2020-03-07T06:52:16Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0147-5185 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79961027006&doi=10.1097%2fPAS.0b013e318219cd0b&partnerID=40&md5=139e4d830a2321766b61d3e7a79747a3 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473712 | - |
dc.description.abstract | Fat-forming solitary fibrous tumor is a rare variant of solitary fibrous tumor (SFT). Generally regarded as benign, very few fat-forming SFTs with malignant histologic features have been reported. Here, we report 14 histologically malignant fat-forming SFTs to better characterize this subset. Seven patients were female and 7 were male, with ages ranging 20 to 93 years (median, 57 y). Five tumors were located in the lower limb, 3 in the trunk, 3 in abdominopelvic locations, 2 in the head and neck region, and 1 in the upper limb. The tumor size ranged from 3.4 to 20 cm (median, 8.6 cm). Histologically, all exhibited at least focal hypercellularity; 12 tumors had mitoses >4/10 high-power fields (range, 2 to 37; median, 8), 12 showed at least moderate atypia, and 8 showed necrosis. It should be noted that 7 tumors contained only mature adipose tissue, whereas 5 contained multivacuolated lipoblasts and 2 had areas resembling atypical lipomatous tumor (ALT). Immunohistochemically, CD34 and CD99 were positive in most cases (11 of 14 and 8 of 10, respectively); MDM2 and CDK4 were both negative in all 4 cases tested (including both tumors with ALT-like areas). Follow-up data from 10 cases (median duration, 47.5 mo; range, 5 to 76) showed 2 patients with multiple metastases (both to lung and bones, and 1 each to breast and to soft tissue), both of whom died of disease. In conclusion, fat-forming SFTs exhibiting malignant histologic features have potential for aggressive behavior. The presence of lipoblasts and/or ALT-like areas, although described in some "benign" examples of fat-forming SFT, seems much more common in the malignant subset and may prompt a careful search for morphologic evidence of malignancy in any case of fat-forming SFT. Copyright ? 2011 by Lippincott Williams & Wilkins. | - |
dc.relation.ispartof | American Journal of Surgical Pathology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | tumor marker; abdominal tumor; adult; aged; article; biopsy; chemistry; female; head and neck tumor; hemangiopericytoma; human; immunohistochemistry; limb; lipoma; male; metastasis; middle aged; mortality; pathology; rectum tumor; soft tissue tumor; solitary fibrous tumor; time; treatment outcome; Abdominal Neoplasms; Adult; Aged; Aged, 80 and over; Biopsy; Extremities; Female; Head and Neck Neoplasms; Hemangiopericytoma; Humans; Immunohistochemistry; Lipoma; Male; Middle Aged; Rectal Neoplasms; Soft Tissue Neoplasms; Solitary Fibrous Tumors; Time Factors; Treatment Outcome; Tumor Markers, Biological; Young Adult | - |
dc.title | Malignant fat-forming solitary fibrous tumor (so-called "lipomatous hemangiopericytoma"): Clinicopathologic analysis of 14 cases | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1097/PAS.0b013e318219cd0b | - |
dc.identifier.pmid | 21716088 | - |
dc.identifier.scopus | 2-s2.0-79961027006 | - |
dc.relation.pages | 1177-1185 | - |
dc.relation.journalvolume | 35 | - |
dc.relation.journalissue | 8 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.orcid | 0000-0001-7739-5934 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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