https://scholars.lib.ntu.edu.tw/handle/123456789/473745
Title: | The Pretreatment Neutrophil-to-Lymphocyte Ratio is a Prognostic Determinant of T3–4 Hypopharyngeal Squamous Cell Carcinoma | Authors: | Lo W.-C. CHEN-TU WU CHENG-PING WANG TSUNG-LIN YANG PEI-JEN LOU JENG-YUH KO YIH-LEONG CHANG |
Issue Date: | 2017 | Publisher: | Springer New York LLC | Journal Volume: | 24 | Journal Issue: | 7 | Start page/Pages: | 1980-1988 | Source: | Annals of Surgical Oncology | Abstract: | Objective: This study aimed to investigate the clinicopathological factors that influence recurrence and survival in patients who undergo operations for T3–4 hypopharyngeal squamous cell carcinomas (SCCs). Materials and Methods: One hundred and five patients who underwent surgery between 2001 and 2008 for advanced hypopharyngeal SCCs were consecutively enrolled and reviewed. Results: The pretreatment neutrophil-to-lymphocyte ratio (NLR; median 3.22, range 0.62–46.50) was associated with disease recurrence and patient survival. A difference in the 5-year cumulative disease recurrence rate between patients with high (?3.22) and low (<3.22) NLRs was significant (60.4 and 36.5%, respectively; p?=?0.004). A multivariate analysis confirmed that an NLR??3.22 was an independent indicator of a poor prognosis for advanced hypopharyngeal SCC, as per the following parameters: overall survival (hazard ratio [HR] 2.53, 95% confidence interval [CI] 1.48–4.30, p?=?0.001), disease-specific survival (HR 2.45, 95% CI 1.38–4.34, p?=?0.002), and disease-free survival (HR 2.18, 95% CI 1.24–3.83, p?=?0.007). Additional prognostic factors per the survival analyses included lymph node density, surgical margin, lymphovascular invasion, and perineural invasion. Conclusions: An NLR??3.22 is associated with a higher risk of disease recurrence and poor survival in patients with T3–4 hypopharyngeal SCCs. We propose the use of the NLR to broaden the current TNM staging system; the development of a more effective treatment protocol for patients with high NLRs will be essential. ? 2017, Society of Surgical Oncology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018835137&doi=10.1245%2fs10434-017-5865-8&partnerID=40&md5=bfb877084eee9cb3b0cb7bbaf88cacbc https://scholars.lib.ntu.edu.tw/handle/123456789/473745 |
ISSN: | 1068-9265 | DOI: | 10.1245/s10434-017-5865-8 | SDG/Keyword: | cisplatin; adjuvant radiotherapy; adult; Article; cancer patient; cancer prognosis; cancer radiotherapy; cancer registry; cancer staging; cancer surgery; cancer survival; disease association; disease free survival; disease specific survival; female; follow up; human; hypopharynx squamous cell carcinoma; major clinical study; male; medical history; middle aged; multimodality cancer therapy; neutrophil lymphocyte ratio; overall survival; perineural invasion; preoperative chemotherapy; recurrent disease; surgical margin; tertiary care center; aged; cancer staging; hypopharynx tumor; lymphocyte; neutrophil; pathology; retrospective study; squamous cell carcinoma; survival rate; tumor invasion; tumor recurrence; very elderly; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypopharyngeal Neoplasms; Lymphocytes; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Neutrophils; Retrospective Studies; Survival Rate |
Appears in Collections: | 病理學科所 |
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