https://scholars.lib.ntu.edu.tw/handle/123456789/473747
Title: | Lymph Node Ratio Predicts Recurrence and Survival for Patients with Resectable Stage 4 Hypopharyngeal Cancer | Authors: | Lo W.-C. CHEN-TU WU CHENG-PING WANG TSUNG-LIN YANG PEI-JEN LOU JENG-YUH KO YIH-LEONG CHANG |
Issue Date: | 2017 | Publisher: | Springer New York LLC | Journal Volume: | 24 | Journal Issue: | 6 | Start page/Pages: | 1707-1713 | Source: | Annals of Surgical Oncology | Abstract: | Background: This study aimed to investigate the clinicopathologic prognostic predictors of stage 4 hypopharyngeal cancer and to extend the traditional tumor-node-metastasis classification system to advance its predictive ability. Methods: The study enrolled 120 patients with pathologically stage 4 hypopharyngeal cancer treated with pharyngolaryngectomy and neck dissection between 2001 and 2007. Results: The study showed a 5-year overall survival (OS) of 44.6%, a disease-specific survival (DSS) of 51.6%, and a disease-free survival (DFS) of 48% for all the patients. In the multivariate analysis, a lymph node (LN) ratio of 0.113 or higher was a significant poor prognostic factor for OS (hazard ratio [HR] 1.89; 95% confidence interval [CI] 1.17–3.05; p?=?0.009), DSS (HR 2.17; 95% CI 1.29–3.64; p?=?0.003), and DFS (HR, 2.24; 95% CI 1.12–4.52; p?=?0.024) in stage 4 hypopharyngeal cancer. In addition, pretreatment neutrophil–lymphocyte ratio, lymphovascular invasion, and margin status also were predictors of survival outcomes. Furthermore, the study found that disease recurrence differed significantly between the patients with a LN ratio of 0.113 or higher (68.2%) and those with a LN ratio lower than 0.113 (39.5%) (p?=?0.002). Conclusions: A LN ratio of 0.113 or higher is a strong predictor of disease recurrence and survival for patients with stage 4 hypopharyngeal cancer. ? 2017, Society of Surgical Oncology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010754922&doi=10.1245%2fs10434-017-5770-1&partnerID=40&md5=b39d8a0638f03f5fb31ce9264092f685 https://scholars.lib.ntu.edu.tw/handle/123456789/473747 |
ISSN: | 1068-9265 | DOI: | 10.1245/s10434-017-5770-1 | SDG/Keyword: | adult; age; aged; Article; bone metastasis; cancer classification; cancer prognosis; cancer recurrence; cancer surgery; cancer survival; disease free survival; disease severity; disease specific survival; female; gender; human; hyoid bone; hypopharynx cancer; laryngectomy; lymph node metastasis; lymph node ratio; lymph vessel metastasis; major clinical study; male; middle aged; neck dissection; neutrophil lymphocyte ratio; overall survival; perineural invasion; primary tumor; surgical margin; thrombocyte count; tumor differentiation; very elderly; follow up; hypopharynx tumor; lymph node; lymph node dissection; mortality; pathology; pharyngectomy; prognosis; retrospective study; survival rate; tumor invasion; tumor recurrence; Adult; Aged; Aged, 80 and over; Female; Follow-Up Studies; Humans; Hypopharyngeal Neoplasms; Lymph Node Excision; Lymph Nodes; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Pharyngectomy; Prognosis; Retrospective Studies; Survival Rate |
Appears in Collections: | 病理學科所 |
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