https://scholars.lib.ntu.edu.tw/handle/123456789/473747
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lo W.-C. | en_US |
dc.contributor.author | CHEN-TU WU | en_US |
dc.contributor.author | CHENG-PING WANG | en_US |
dc.contributor.author | TSUNG-LIN YANG | en_US |
dc.contributor.author | PEI-JEN LOU | en_US |
dc.contributor.author | JENG-YUH KO | en_US |
dc.contributor.author | YIH-LEONG CHANG | en_US |
dc.creator | Lo W.-C.;Wu C.-T.;Wang C.-P.;Yang T.-L.;Lou P.-J.;Ko J.-Y.;Yih-Leong Chang | - |
dc.date.accessioned | 2020-03-07T06:56:14Z | - |
dc.date.available | 2020-03-07T06:56:14Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010754922&doi=10.1245%2fs10434-017-5770-1&partnerID=40&md5=b39d8a0638f03f5fb31ce9264092f685 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473747 | - |
dc.description.abstract | Background: This study aimed to investigate the clinicopathologic prognostic predictors of stage 4 hypopharyngeal cancer and to extend the traditional tumor-node-metastasis classification system to advance its predictive ability. Methods: The study enrolled 120 patients with pathologically stage 4 hypopharyngeal cancer treated with pharyngolaryngectomy and neck dissection between 2001 and 2007. Results: The study showed a 5-year overall survival (OS) of 44.6%, a disease-specific survival (DSS) of 51.6%, and a disease-free survival (DFS) of 48% for all the patients. In the multivariate analysis, a lymph node (LN) ratio of 0.113 or higher was a significant poor prognostic factor for OS (hazard ratio [HR] 1.89; 95% confidence interval [CI] 1.17–3.05; p?=?0.009), DSS (HR 2.17; 95% CI 1.29–3.64; p?=?0.003), and DFS (HR, 2.24; 95% CI 1.12–4.52; p?=?0.024) in stage 4 hypopharyngeal cancer. In addition, pretreatment neutrophil–lymphocyte ratio, lymphovascular invasion, and margin status also were predictors of survival outcomes. Furthermore, the study found that disease recurrence differed significantly between the patients with a LN ratio of 0.113 or higher (68.2%) and those with a LN ratio lower than 0.113 (39.5%) (p?=?0.002). Conclusions: A LN ratio of 0.113 or higher is a strong predictor of disease recurrence and survival for patients with stage 4 hypopharyngeal cancer. ? 2017, Society of Surgical Oncology. | en_US |
dc.publisher | Springer New York LLC | en_US |
dc.relation.ispartof | Annals of Surgical Oncology | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adult; age; aged; Article; bone metastasis; cancer classification; cancer prognosis; cancer recurrence; cancer surgery; cancer survival; disease free survival; disease severity; disease specific survival; female; gender; human; hyoid bone; hypopharynx cancer; laryngectomy; lymph node metastasis; lymph node ratio; lymph vessel metastasis; major clinical study; male; middle aged; neck dissection; neutrophil lymphocyte ratio; overall survival; perineural invasion; primary tumor; surgical margin; thrombocyte count; tumor differentiation; very elderly; follow up; hypopharynx tumor; lymph node; lymph node dissection; mortality; pathology; pharyngectomy; prognosis; retrospective study; survival rate; tumor invasion; tumor recurrence; Adult; Aged; Aged, 80 and over; Female; Follow-Up Studies; Humans; Hypopharyngeal Neoplasms; Lymph Node Excision; Lymph Nodes; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Pharyngectomy; Prognosis; Retrospective Studies; Survival Rate | - |
dc.title | Lymph Node Ratio Predicts Recurrence and Survival for Patients with Resectable Stage 4 Hypopharyngeal Cancer | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1245/s10434-017-5770-1 | - |
dc.identifier.pmid | 28130622 | - |
dc.identifier.scopus | 2-s2.0-85010754922 | - |
dc.relation.pages | 1707-1713 | en_US |
dc.relation.journalvolume | 24 | en_US |
dc.relation.journalissue | 6 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Pathology-NTUCC | - |
crisitem.author.orcid | 0000-0001-8458-4119 | - |
crisitem.author.orcid | 0000-0001-7872-1463 | - |
crisitem.author.orcid | 0000-0001-6521-8631 | - |
crisitem.author.orcid | 0000-0002-3383-8593 | - |
crisitem.author.orcid | 0000-0002-2538-558X | - |
crisitem.author.orcid | 0000-0001-5309-0554 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
顯示於: | 病理學科所 |
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