|Title:||Regular screening of esophageal cancer for 248 newly diagnosed hypopharyngeal squamous cell carcinoma by unsedated transnasal esophagogastroduodenoscopy||Authors:||Huang Y.-C.
|Issue Date:||2016||Publisher:||Elsevier Ltd||Journal Volume:||55||Start page/Pages:||55-60||Source:||Oral Oncology||Abstract:||
SummaryObjectives Esophageal squamous cell carcinoma (ESCC) is common in hypopharyngeal squamous cell carcinoma (HSCC) patients. This prospective study is to reveal the prevalence of simultaneous ESCC in newly diagnosed HSCC patients by unsedated transnasal esophagogastroduodenoscopy (EGD) and to analyze the clinical predictors for simultaneous esophageal lesions and their survival. Materials and methods 248 patients with newly diagnosed HSCC and without previous head and neck cancer between 2007 and 2014 were prospectively evaluated for HSCC and simultaneous esophageal lesions by unsedated transnasal EGD. The clinical factors for simultaneous esophageal lesions were evaluated. Survival analysis of the HSCC patients receiving complete treatment was done. Results The mean age was 58 years. 170 HSCC (68.5%) were classified as T3-T4. The procedures were successfully performed (98.4%), except 4 huge tumors. 174 HSCC (85.7%, out of 203 tumors biopsied) were pathologically proved malignancy by this technique. Regarding esophageal lesions (45.5%), ESCC occurred in 36 patients (14.8%), dysplasia without ESCC occurred in 23 (9.4%) and Lugol voiding lesion without ESCC or dysplasia occurred in 52 (21.3%). Alcohol drinking (adjusted OR: 6.95, p < 0.05) and N3 classification (adjusted OR: 2.41, p < 0.05) of HSCC were the independent risk factors for the presence of esophageal lesions. The overall survival of the HSCC patients with ESCC was significantly lower than those without ESCC (p = 0.013). Conclusions Unsedated transnasal EGD is a promising technique for diagnosis of HSCC and simultaneous ESCC. Simultaneous esophageal lesions including ESCC (15%) are common in newly diagnosed HSCC patients, especially with alcohol drinking or N3 disease. ? 2016 Elsevier Ltd.
|ISSN:||1368-8375||DOI:||10.1016/j.oraloncology.2016.01.008||SDG/Keyword:||adult; aged; Article; cancer classification; cancer screening; cancer survival; drinking behavior; dysplasia; esophageal squamous cell carcinoma; esophagogastroduodenoscopy; esophagus cancer; female; head and neck cancer; human; hypopharyngeal squamous cell carcinoma; major clinical study; male; overall survival; predictive value; prevalence; priority journal; risk factor; Carcinoma, Squamous Cell; digestive tract endoscopy; Esophageal Neoplasms; Hypopharyngeal Neoplasms; middle aged; procedures; prospective study; very elderly; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Endoscopy, Digestive System; Esophageal Neoplasms; Female; Humans; Hypopharyngeal Neoplasms; Male; Middle Aged; Prevalence; Prospective Studies; Risk Factors
|Appears in Collections:||病理學科所|
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