https://scholars.lib.ntu.edu.tw/handle/123456789/473770
標題: | Papillary-cystic pattern is characteristic in mammary analogue secretory carcinomas but is rarely observed in acinic cell carcinomas of the salivary gland | 作者: | MIN-SHU HSIEH Chou Y.-H. SHIN-JOE YEH YIH-LEONG CHANG |
公開日期: | 2015 | 出版社: | Springer Verlag | 卷: | 467 | 期: | 2 | 起(迄)頁: | 145-153 | 來源出版物: | Virchows Archiv | 摘要: | Mammary analogue secretory carcinoma (MASC) has a specific ETV6-NTRK3 translocation and morphologically overlaps with acinic cell carcinoma (AciCC). Before the recognition of MASC, in AciCC, four histologic patterns were identified including microcystic, solid, papillary-cystic, and follicular. The aim of this study was to evaluate histologic patterns in these two neoplasms through comprehensive histologic subtyping. Using fluorescence in situ hybridization (FISH), we identified 14 cases of MASC and 21 cases of AciCC. We used comprehensive histologic subtyping to provide a semiquantitive assessment of histologic patterns in each tumor and performed immunohistochemical analyses including S100/vimentin/mammaglobin/DOG1. MASC often presented papillary-cystic patterns without a solid component, previously considered to be one of the four major patterns associated with AciCC. However, in our study, this histologic feature was rarely seen in AciCC and more characteristic of MASC. In aspiration cytology samples, MASC was associated with more cellular atypia. An immunohistochemical panel of S100/mammaglobin/DOG1 was found useful for differential diagnosis. Comprehensive subtyping of histologic patterns is a useful screening method prior to initiation of molecular testing. ? 2015, Springer-Verlag Berlin Heidelberg. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938979234&doi=10.1007%2fs00428-015-1786-8&partnerID=40&md5=a54f7bbb46a5d93e9199ea73f7894d80 https://scholars.lib.ntu.edu.tw/handle/123456789/473770 |
ISSN: | 0945-6317 | DOI: | 10.1007/s00428-015-1786-8 | SDG/關鍵字: | mammaglobin; protein S 100; transcription factor ETV6; vimentin; ETV6-NTRK3 fusion protein, human; oncoprotein; tumor marker; acinar cell carcinoma; adolescent; adult; aged; Article; aspiration cytology; cancer recurrence; cancer screening; cancer size; cancer staging; clinical article; clinical feature; controlled study; differential diagnosis; female; fluorescence in situ hybridization; gene translocation; histology; human; human tissue; immunohistochemistry; lymph node metastasis; male; mammary analogue secretory carcinoma; molecular diagnosis; priority journal; salivary gland cancer; acinar cell carcinoma; genetics; metabolism; middle aged; pathology; polymerase chain reaction; salivary gland tumor; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Acinar Cell; Female; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Male; Middle Aged; Oncogene Proteins, Fusion; Polymerase Chain Reaction; Salivary Gland Neoplasms; Tumor Markers, Biological; Young Adult |
顯示於: | 病理學科所 |
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