https://scholars.lib.ntu.edu.tw/handle/123456789/473792
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | MONG-WEI LIN | en_US |
dc.contributor.author | CHEN-TU WU | en_US |
dc.contributor.author | JIN-YUAN SHIH | en_US |
dc.contributor.author | YIH-LEONG CHANG | en_US |
dc.contributor.author | PAN-CHYR YANG | en_US |
dc.creator | Lin M.-W.;Wu C.-T.;Shih J.-Y.;Yih-Leong Chang;Yang P.-C. | - |
dc.date.accessioned | 2020-03-07T06:56:27Z | - |
dc.date.available | 2020-03-07T06:56:27Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903940270&doi=10.1002%2fjso.23628&partnerID=40&md5=b437e2f0ed69eb0c5a611bfeef56120c | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473792 | - |
dc.description.abstract | Background and Objectives Small lung adenocarcinomas are detected more frequently than in the past. However, the clinicopathologic characteristics and prognostic significance of EGFR/p53 mutations in these tumors remains unclear. Methods We evaluated the correlation of EGFR/p53 mutations with clinicopathologic characteristics and tumor relapse in 172 surgically resected lung adenocarcinomas ?2 cm in maximal dimension. EGFR/p53 mutational analysis was performed on DNA extracted from paraffin-embedded tumors. Results EGFR and p53 mutations were identified in 104 (60.5%) and 36 (20.9%) small adenocarcinomas, respectively. EGFR/p53 mutations were associated with tumor size >1 cm, whereas p53 mutations were frequently observed in moderately differentiated tumors. Disease-free survival analysis showed that p53 mutation, presence of visceral pleural surface invasion, elevated preoperative serum carcinoembryonic antigen, and moderate histologic differentiation were significantly correlated with tumor relapse in patients with stage I disease. The 5-year survival rate was higher in relapsed patients with EGFR-mutated tumors who were treated with tyrosine kinase inhibitor (TKI) than in those who were not treated with TKI. Conclusions p53 mutation was significantly correlated with tumor progression, and our findings may provide a rationale for the selective use of adjuvant chemotherapy in stage IB patients with p53 mutations. EGFR mutation was a predictor of EGFR TKI response in relapsed patients. ? 2014 Wiley Periodicals, Inc. | - |
dc.publisher | John Wiley and Sons Inc. | - |
dc.relation.ispartof | Journal of Surgical Oncology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | carcinoembryonic antigen; epidermal growth factor receptor; protein p53; protein tyrosine kinase inhibitor; adult; aged; article; cancer recurrence; cancer staging; cancer surgery; cancer survival; cell differentiation; correlation analysis; disease free survival; female; gene mutation; human; human tissue; lung adenocarcinoma; lung alveolus cell carcinoma; lymph node metastasis; major clinical study; male; missense mutation; mutational analysis; overall survival; preoperative period; priority journal; risk factor; survival rate; tumor volume; epidermal growth factor receptor; lung adenocarcinoma; p53; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; DNA Mutational Analysis; DNA, Neoplasm; Enzyme Inhibitors; Female; Genes, erbB-1; Genes, p53; Genetic Markers; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Neoplasm Recurrence, Local; Neoplasm Staging; Pneumonectomy; Prognosis; Protein-Tyrosine Kinases; Survival Analysis; Tumor Burden; Tumor Markers, Biological | - |
dc.title | Clinicopathologic characteristics and prognostic significance of EGFR and p53 mutations in surgically resected lung adenocarcinomas ≤2 cm in maximal dimension | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/jso.23628 | - |
dc.identifier.pmid | 24788590 | - |
dc.identifier.scopus | 2-s2.0-84903940270 | - |
dc.relation.pages | 99-106 | - |
dc.relation.journalvolume | 110 | - |
dc.relation.journalissue | 2 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Pathology-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-1268-3729 | - |
crisitem.author.orcid | 0000-0001-8458-4119 | - |
crisitem.author.orcid | 0000-0002-2854-5067 | - |
crisitem.author.orcid | 0000-0001-5309-0554 | - |
crisitem.author.orcid | 0000-0001-6330-6048 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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