https://scholars.lib.ntu.edu.tw/handle/123456789/473822
標題: | Tumor satellite in predicting occult nodal metastasis of tongue cancer | 作者: | TSUNG-LIN YANG PEI-JEN LOU YIH-LEONG CHANG CHEN-TU WU CHENG-PING WANG JENG-YUH KO |
公開日期: | 2011 | 卷: | 145 | 期: | 4 | 起(迄)頁: | 599-605 | 來源出版物: | Otolaryngology - Head and Neck Surgery | 摘要: | Objective. Tongue cancer is well known to have a high potential for locoregional metastasis. However, controversy about electively treating the neck in early-stage tongue cancer remains. Although many risk factors related to cervical occult nodal metastasis (ONM) have been investigated, the ability of the tumor to spread, a phenomenon that results from the intrinsic property of the tumor and its interaction with the surrounding environment, has seldom been addressed. Study Design. Retrospective case series with chart review. Setting. Tertiary referral hospital of university. Subjects. Patients with early-stage squamous cell carcinoma of the oral tongue. Results. In 71 eligible enrolled patients, ONM was detected in 19 (27%) patients, while the results were negative (ONM(-)) in 52 (73%) patients. The average tumor satellite distance (TSD) in the ONM(+) group was 4.1 ± 4.3 mm, in contrast to that in the ONM(-) group (1.0 ± 1.5 mm; P < .001). When stratified by increased TSD values, the significance of the difference between the 2 groups increased. For clinical applications, the optimal TSD threshold for determining the ONM probability was 3.5 mm. Multivariate analyses demonstrated that TSD was an independent prognosticator. Conclusions. The results indicate that TSD is a feasible pathological parameter that is useful for determining the status of cervical nodal metastasis. It can be used as an indicator of potential cervical subclinical disease and as a guideline for deciding the necessity and modality of neck treatment. ? American Academy of Otolaryngology-Head and Neck Surgery Foundation 2011. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856378432&doi=10.1177%2f0194599811411635&partnerID=40&md5=cc6782c4f504b88c841fe2b6b32cf798 https://scholars.lib.ntu.edu.tw/handle/123456789/473822 |
ISSN: | 0194-5998 | DOI: | 10.1177/0194599811411635 | SDG/關鍵字: | adult; article; cancer diagnosis; cancer invasion; clinical evaluation; female; histopathology; human; human tissue; major clinical study; male; metastasis; occult nodal metastasis; oncological parameters; risk assessment; tongue cancer; tumor satellite distance; aged; lymph node metastasis; middle aged; multivariate analysis; pathology; receiver operating characteristic; squamous cell carcinoma; tongue tumor; Adult; Aged; Carcinoma, Squamous Cell; Female; Humans; Lymphatic Metastasis; Male; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; ROC Curve; Tongue Neoplasms; Young Adult |
顯示於: | 病理學科所 |
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