https://scholars.lib.ntu.edu.tw/handle/123456789/473863
標題: | Postirradiated neuroendocrine carcinoma of the sinonasal tract | 作者: | CHENG-PING WANG Hsieh C.-Y. YIH-LEONG CHANG PEI-JEN LOU TSUNG-LIN YANG Ting L.-L. JENG-YUH KO |
公開日期: | 2008 | 卷: | 118 | 期: | 5 | 起(迄)頁: | 804-809 | 來源出版物: | Laryngoscope | 摘要: | OBJECTIVES/HYPOTHESIS: Neuroendocrine carcinoma (NEC) of the sinonasal tract is rare. In this present study, we report our treatment experience with sinonasal NEC. STUDY DESIGN: Retrospective case series. METHODS: A retrospective review of the clinical outcomes and pathology of 18 patients with NEC arising from the sinonasal region. RESULTS: Ten tumors were primary NEC without previous radiation, and eight tumors were postirradiated NEC occurring within the radiation field for previous nasopharyngeal carcinoma in six patients and tonsillar lymphoma in one and neck metastasis of unknown primary origin in one, with an interval between previous radiotherapy and diagnosis of NEC from 82 to 385 months, with a mean of 197 months. Fifteen tumors were small cell carcinoma, two were atypical carcinoid, and one was typical carcinoid tumor. Fifteen patients underwent surgery with/without postoperative adjuvant chemoradiotherapy. Three patients received induction chemotherapy or primary radiotherapy with further definitive treatment. The 5-year disease-free and overall survival rates of all 18 patients were 56.1% and 62.2%, respectively. In comparing primary NEC with postirradiated NEC, they were similar in age, sex distribution, stage, pathology, and treatment, and the 5-year overall survival rates were 70% and 62.5%, respectively. CONCLUSIONS: In this series, postirradiated NEC is common, which may be the result of there being a large number of long-term nasopharyngeal carcinoma survivors. The prognoses of postirradiated NEC and primary NEC appear to be similar despite the relatively short follow-up period in the postirradiated NEC group. ? The American Laryngological, Rhinological & Otological Society, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-43049127462&doi=10.1097%2fMLG.0b013e3181671491&partnerID=40&md5=17818b253c98a3be00b62a1508df050b https://scholars.lib.ntu.edu.tw/handle/123456789/473863 |
ISSN: | 0023-852X | DOI: | 10.1097/MLG.0b013e3181671491 | SDG/關鍵字: | antineoplastic agent; adult; aged; article; cancer radiotherapy; cancer surgery; cancer survival; clinical article; controlled study; ethmoid sinus; female; human; male; maxillary sinus; nasopharynx carcinoma; neck metastasis; neuroendocrine tumor; nose cavity; paranasal sinus carcinoma; priority journal; small cell carcinoma; survival rate; tonsil cancer; treatment outcome; Adult; Aged; Carcinoma, Neuroendocrine; Carcinoma, Small Cell; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Lymphoma; Male; Maxillary Neoplasms; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Staging; Neoplasms, Second Primary; Radiotherapy Dosage; Retrospective Studies; Tonsillar Neoplasms |
顯示於: | 病理學科所 |
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