https://scholars.lib.ntu.edu.tw/handle/123456789/473886
標題: | Photodynamic therapy with topical 5-aminolevulinic acid as a post-operative adjuvant therapy for an incompletely resected primary nasopharyngeal papillary adenocarcinoma: A case report | 作者: | CHENG-PING WANG YIH-LEONG CHANG Chen C.-T. TING-HUA YANG PEI-JEN LOU |
公開日期: | 2006 | 卷: | 38 | 期: | 5 | 起(迄)頁: | 435-438 | 來源出版物: | Lasers in Surgery and Medicine | 摘要: | Background and Objectives: Surgical excision of primary nasopharyngeal papillary adenocarcinoma is sometimes incomplete with remaining microscopic disease. Postoperative radiotherapy only has limited efficacy but may cause many complications. Study Design/Materials and Methods: Photodynamic therapy (PDT) was used as a post-operative adjuvant therapy for an incompletely resected primary nasopharyngeal papillary adenocarcinoma. A special form of 20% topical 5-aminolevulinic acid (5-ALA), which was originally a liquid form and became a gel form after applied on the nasopharynx, was used as the photosensitizer. A 2-mm optic fiber delivered the light (633 nm wavelength) to the lesion with a fluence rate of 100 mW/cm2 generated by a diode laser under 5 mm 0° endoscope assistance. The total energy delivered was 150 joules/cm 2. Results: No significant acute side effect was noted and the nasopharyngeal wound healed rapidly. The patient is alive without locoregional recurrence or distant metastasis for 5 years. Articulation, salivation, and swallowing functions are all well preserved. Conclusion: Post-operative adjuvant PDT can successfully cure an otherwise difficult to treat disease with preservation of good life quality of the patient. Potential complications of PDT (e.g., photosensitivity) can be prevented by a special formulation of topical 5-ALA preparation. ? 2006 Wiley-Liss, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33745727957&doi=10.1002%2flsm.20291&partnerID=40&md5=113e53616ddde89b3d61ca0883072afc https://scholars.lib.ntu.edu.tw/handle/123456789/473886 |
ISSN: | 0196-8092 | DOI: | 10.1002/lsm.20291 | SDG/關鍵字: | aminolevulinic acid; carbomer; carbopol 971p; photosensitizing agent; poloxamer; absence of side effects; adenocarcinoma; adjuvant therapy; adult; article; cancer survival; case report; computer assisted tomography; drug formulation; female; head and neck carcinoma; human; nasopharynx carcinoma; photodynamic therapy; photosensitivity disorder; priority journal; treatment outcome; wound healing; Adenocarcinoma, Papillary; Administration, Topical; Adult; Aminolevulinic Acid; Combined Modality Therapy; Female; Humans; Nasopharyngeal Neoplasms; Photochemotherapy; Photosensitizing Agents; Postoperative Care; Treatment Outcome |
顯示於: | 病理學科所 |
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