https://scholars.lib.ntu.edu.tw/handle/123456789/473940
標題: | The significance of E-cadherin and α-, β-, and γ-catenin expression in surgically treated non-small cell lung cancers of 3 cm or less in size | 作者: | Lee Y.-C. CHEN-TU WU Chen C.-S. HSAO-HSUN HSU YIH-LEONG CHANG |
公開日期: | 2002 | 出版社: | Mosby Inc. | 卷: | 123 | 期: | 3 | 起(迄)頁: | 502-507 | 來源出版物: | Journal of Thoracic and Cardiovascular Surgery | 摘要: | Objectives: Expression of the cell-cell adhesion molecules E-cadherin and α-, β-, and γ-catenin seems closely related to tumor invasiveness. The relationship between the expression and clinicopathologic characteristics in surgically resected non-small cell lung cancers of 3 cm or less in size was studied. The relationship to patient survival was analyzed. Methods: A total of 115 patients with surgically resected lung cancers of 3 cm or less in size were enrolled in this study. Expression of E-cadherin and α-, β-, and γ-catenin was immunohistochemically measured. The χ2 test was used to correlate this expression with clinicopathologic parameters. Their influence on patient survival was evaluated with the Cox proportional hazards model. Results: There was a positive correlation between E-cadherin and catenin expression in lung cancers. In general, E-cadherin and catenin expression were greater in tumors that were either bronchioloalveolar carcinomas or adenocarcinomas, well differentiated, early stage, peripheral, and without vascular or pleural invasion. By using multicovariate analysis of patient survival, only early-stage and peripheral tumors were significantly favorable prognostic factors. Further analysis of the group of patients with early-stage disease showed that higher α-, β-, or γ-catenin expression was a favorable prognostic indicator. Conclusion: Expression of α-, β-, or γ-catenin can be used as a prognostic indicator in patients with surgically resected stage I non-small cell lung cancers of 3 cm or less in size. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036521335&doi=10.1067%2fmtc.2002.119334&partnerID=40&md5=ac35a841989f9b66c201c980eeab9c7f https://scholars.lib.ntu.edu.tw/handle/123456789/473940 |
ISSN: | 0022-5223 | DOI: | 10.1067/mtc.2002.119334 | SDG/關鍵字: | alpha catenin; beta catenin; plakoglobin; uvomorulin; adult; aged; article; cancer invasion; cancer size; cancer surgery; cancer survival; controlled study; female; human; human cell; immunohistochemistry; lung adenocarcinoma; lung alveolus cell carcinoma; lung non small cell cancer; major clinical study; male; nonbiological model; priority journal; protein expression; tumor differentiation |
顯示於: | 病理學科所 |
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