https://scholars.lib.ntu.edu.tw/handle/123456789/473954
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lee Y.-C. | en_US |
dc.contributor.author | CHEN-TU WU | en_US |
dc.contributor.author | Luh S.-P. | en_US |
dc.contributor.author | JANG-MING LEE | en_US |
dc.contributor.author | Chen C.-S. | en_US |
dc.contributor.author | YIH-LEONG CHANG | en_US |
dc.creator | Lee Y.-C.;Wu C.-T.;Luh S.-P.;Lee J.-M.;Chen C.-S.;Yih-Leong Chang | - |
dc.date.accessioned | 2020-03-07T06:57:09Z | - |
dc.date.available | 2020-03-07T06:57:09Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0171-6425 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033790650&doi=10.1055%2fs-2000-7885&partnerID=40&md5=2b1c520fdd9c40349deff405230e3aec | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473954 | - |
dc.description.abstract | Background: E-Cadherin is a subclass of the cadherin family that plays a major role in the maintenance of intercellular junctions in normal epithelium. Decreased expression of E-cadherin might be closely related to invasiveness and dedifferentiation in human cancers. This study is aimed at investigating the clinicopathological significance of E-cadherin expression and its impact on the prognosis in surgically resected non-small-cell lung cancer patients. Methods: Using immunohistochemical staining, the expression of E-cadherin was studied in 207 surgically resected lung cancer specimens from January 1990 through December 1994. The clinicopathological data and survival status were recorded and analysed against the E-cadherin expression level in each tumor. Results: E-cadherin expression was detected in 122 of the 207 lung tumors (59.0%), and the expression was significantly lower in tumors with poor differentiation (p < 0.001), in tumors with vascular invasion (p < 0.05), and in tumors with direct invasion into surrounding structures (p < 0.01). There was no correlation between E-cadherin expression, and tumor stage and regional lymph-node metastasis. There was no significant difference in survival rate between higher (> 40%) and lower (< 40%) E-cadherin expression groups; however, in tumors 3 cm or less, a significant difference was found between higher and lower E-cadherin expressions (p < 0.0001). Conclusions: Underexpression of E-cadherin is associated with poor differentiation and invasiveness in NSCLC. In patients with small NSCLC (? 3 cm), higher E-cadherin expression (> 40%) significantly had a favorable prognosis. | - |
dc.relation.ispartof | Thoracic and Cardiovascular Surgeon | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | uvomorulin; adult; aged; article; cancer invasion; cancer staging; cell differentiation; cell junction; female; human; human tissue; immunohistochemistry; lung non small cell cancer; lymph node metastasis; major clinical study; male; pathology; priority journal; prognosis; protein expression; protein family; survival rate; tumor volume; Adult; Aged; Aged, 80 and over; Biological Markers; Cadherins; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Survival Rate | - |
dc.title | E-Cadherin expression in surgically-resected non-small cell lung cancers - A clinicopathological study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1055/s-2000-7885 | - |
dc.identifier.pmid | 11100763 | - |
dc.identifier.scopus | 2-s2.0-0033790650 | - |
dc.relation.pages | 294-299 | - |
dc.relation.journalvolume | 48 | - |
dc.relation.journalissue | 5 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Pathology-NTUCC | - |
crisitem.author.orcid | 0000-0001-8458-4119 | - |
crisitem.author.orcid | 0000-0001-9727-227X | - |
crisitem.author.orcid | 0000-0001-5309-0554 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
顯示於: | 病理學科所 |
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