https://scholars.lib.ntu.edu.tw/handle/123456789/474261
標題: | A wireless Bio-MEMS sensor for C-reactive protein detection based on nanomechanics | 作者: | Chen, Chun-Hao Nai-Kuan Chou SHEY-SHI LU SHI-MING LIN Huang, Long-Sun Lin, Shi-Ming Chen, Hsiao-Chin Yang, Yu-Che Lin, Yu-Tso Yu, Shih-An NAI-KUAN CHOU Wang, Yiao-Hong Chou, Nai-Kuan Lu, Shey-Shi |
公開日期: | 2009 | 卷: | 56 | 期: | 2 | 起(迄)頁: | 462-470 | 來源出版物: | IEEE Transactions on Biomedical Engineering | 摘要: | A quick wireless label-free detection of disease-related C-reactive proteins (CRPs) using a 200- \mum-long microelectromechanical systems (MEMS) microcantilever housed in a \hbox{7} \times \hbox{7}\ \hbox{mm}^{2} reaction chamber with a safe reusable feature is reported. The assay time ranges from about 30 min to 3 h, depending on accuracy. The deflection of the microcantilever due to specific CRPantiCRP binding is detected using a position-sensitive detector. The converted bio-signal is transmitted by a custom designed wireless amplitude-shift-keying (ASK) transceiver IC fabricated in a 0.18 mu m CMOS process. CRP concentrations from 1 mug/mL to 500 mug/mL can be detected. A 0.2-Hz 1-V ac signal instead of traditional bases/acids is applied to the bio-MEMS sensor to unbind the CRP from the microcantilever for reusability. ? 2006 IEEE. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-63849105471&doi=10.1109%2fTBME.2008.2003262&partnerID=40&md5=aabb9039d0a0544b809ca30cf1931316 https://scholars.lib.ntu.edu.tw/handle/123456789/474261 |
ISSN: | 0018-9294 | DOI: | 10.1109/TBME.2008.2003262 | SDG/關鍵字: | Amplitude-shift-keying (ASK) receiver; Analog-to-digital converter (ADC); AntiCRP; ASK transmitter; C-reactive protein (CRP); Label-free; Microcantilever; Microcontrol unit (MCU); Poly-dimethyl-siloxane (PDMS); Atomic force microscopy; Composite micromechanics; Electromechanical devices; Frequency converters; Labels; Microchannels; Microsensors; Multicarrier modulation; Reusability; Silicones; Transmitters; MEMS; C reactive protein; dimeticone; amplitude modulation; analog digital converter; article; human; mathematical analysis; microelectromechanical system; molecular mechanics; process monitoring; protein analysis; protein binding; wireless communication; Biosensing Techniques; C-Reactive Protein; Cardiovascular Diseases; Dimethylpolysiloxanes; Equipment Design; Equipment Reuse; Humans; Micro-Electrical-Mechanical Systems; Monitoring, Ambulatory; Nanotechnology; Signal Processing, Computer-Assisted |
顯示於: | 醫學系 |
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