https://scholars.lib.ntu.edu.tw/handle/123456789/474476
標題: | Plasma reactive oxygen species levels are correlated with severity of age-related hearing impairment in humans | 作者: | Hwang J.-H. Chen J.-C. Hsu C.-J. WEI-SHIUNG YANG TIEN-CHEN LIU |
公開日期: | 2012 | 卷: | 33 | 期: | 9 | 起(迄)頁: | 1920-1926 | 來源出版物: | Neurobiology of Aging | 摘要: | To investigate the relationship between plasma reactive oxygen species (ROS) levels and severity of age-related hearing impairment in humans. We recruited 302 adult subjects aged 40-77 years with normal or symmetrical sensorineural hearing loss. The association of plasma ROS levels on pure tone average of low frequencies (PTA-low) and pure tone average of high frequencies (PTA-high) were analyzed. Luminol-dependent chemiluminescence signals, which reflect hydrogen peroxide (H2O2), hypochlorite (HOCl/OCl-) and hydroxyl radicals (?OH) levels, showed significant positive association with PTA-low and PTA-high after adjusting for age, gender, central obesity, systemic diseases, and health-related habits (smoking, drinking, antioxidant intake). Lucigenin-dependent chemiluminescence signals, which mainly reflect superoxide anion (O2?-) levels, showed significant positive association with PTA-low, but not with PTA-high after adjusting for other variables. We concluded that plasma ROS levels were associated with severity of age-related hearing impairment in humans. Various ROS may differently affect auditory dysfunctions. ? 2012 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863495842&doi=10.1016%2fj.neurobiolaging.2011.10.012&partnerID=40&md5=b6f2c365b60731be17ac3b4e097352af https://scholars.lib.ntu.edu.tw/handle/123456789/474476 |
ISSN: | 0197-4580 | DOI: | 10.1016/j.neurobiolaging.2011.10.012 | SDG/關鍵字: | reactive oxygen metabolite; adult; age; aged; article; auditory threshold; disease association; disease severity; female; genetic risk; hearing impairment; human; lifestyle; low frequency noise; major clinical study; male; priority journal; pure tone audiometry; systemic disease; Adult; Aged; Aging; Analysis of Variance; Audiometry, Pure-Tone; Auditory Threshold; Body Height; Body Weight; Female; Hearing Loss; Humans; Hydrogen Peroxide; Hydroxyl Radical; Hypochlorous Acid; Male; Middle Aged; Reactive Oxygen Species; Retrospective Studies |
顯示於: | 醫學系 |
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