|Title:||211 G to A variation of UDP-glucuronosyl transferase 1A1 gene and neonatal Breastfeeding jaundice||Authors:||HUNG-CHIEH CHOU
|Issue Date:||2011||Journal Volume:||69||Journal Issue:||2||Start page/Pages:||170-174||Source:||Pediatric Research||Abstract:||
Breastfeeding jaundice is a common problem in neonates who were exclusively breastfed, but its pathogenesis is still unclear. The uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphism was shown to contribute to the development of neonatal hyperbilirubinemia. We hypothesize that the variation of UGT1A1 gene may contribute to neonatal breastfeeding jaundice. We prospectively enrolled 688 near-term and term infants who were exclusively breastfed (BF group) or were supplemented by infant formula partially (SF group) before onset of hyperbilirubinemia. Genotyping of the promoter and exon1 of UGT1A1 was performed in all neonates. Neonates in BF group had a significantly higher maximal body weight loss ratio, peak bilirubin level, and a greater incidence of hyperbilirubinemia than those in SF group. Neonates with nucleotide 211 GA or AA variation in UGT1A1 genotypes had higher peak serum bilirubin levels and higher incidence of hyperbilirubinemia than WTs (GG). This phenomenon was only seen in BF group but not in SF group when subset analysis was performed. This suggests that neonates who carry the nucleotide 211 GA or AA variation within coding region in UGT1A1 gene are more susceptible to develop early-onset neonatal breastfeeding jaundice. Copyright ? 2011 International Pediatric Research Foundation, Inc.
|ISSN:||0031-3998||DOI:||10.1203/PDR.0b013e31820263d2||SDG/Keyword:||bilirubin; glucuronosyltransferase 1A1; article; artificial milk; bilirubin blood level; breast feeding; controlled study; exon; female; genetic code; genetic polymorphism; genetic susceptibility; genetic variability; genotype; human; incidence; major clinical study; male; newborn; newborn jaundice; phototherapy; priority journal; promoter region; risk factor; weight reduction; Bilirubin; Bottle Feeding; Breast Feeding; Chi-Square Distribution; Exons; Female; Genetic Predisposition to Disease; Glucuronosyltransferase; Humans; Hyperbilirubinemia, Neonatal; Infant Formula; Infant, Newborn; Jaundice, Neonatal; Linear Models; Logistic Models; Male; Odds Ratio; Phenotype; Polymorphism, Genetic; Promoter Regions, Genetic; Prospective Studies; Risk Assessment; Risk Factors
|Appears in Collections:||醫學教育暨生醫倫理學科所|
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