https://scholars.lib.ntu.edu.tw/handle/123456789/475233
標題: | Effects of particulate air pollution and ozone on lung function in non-asthmatic children | 作者: | CHI-HSIEN CHEN CHANG-CHUAN CHAN Chen B.-Y. TSUN-JEN CHENG Yue Leon Guo |
公開日期: | 2015 | 出版社: | Academic Press Inc. | 卷: | 137 | 起(迄)頁: | 40-48 | 來源出版物: | Environmental Research | 摘要: | Introduction: Information on the long-term effects of different air pollutant levels on lung function is relatively lacking in Asia and still inconclusive in the world. Age differential effects of air pollution are not known. Objectives: To assess the acute and subchronic effects of ambient air pollution on lung function and compared among children of different ages. Methods: From April to May 2011, a nationwide study was conducted on schoolchildren aged 6-15 years in 44 schools of 24 districts in Taiwan. Spirograms were obtained from 1494 non-asthmatic children. Air pollution data were retrieved from air monitoring stations within one kilometre of the schools. Using three-level hierarchical linear models, individual lung function was fitted to air pollution, with adjustments for demographics, indoor exposures, outdoor activity, and districts. Results: Lung function changes per inter-quartile increase of the past two-months average levels of particulate matter <2.5μm (PM2.5) and ozone (12μg/m3, 32-44 and 6.7ppb, 32-38, respectively) were -103 and -142ml on FVC, -86 and -131 on FEV1, and -102 and -188ml/s on MMEF, respectively. Lag-1-day ozone exposure was associated with decreased MMEF. In children aged 6-10, PM2.5 was associated with decreased FEV1/FVC and MMEF/FVC ratios. Conclusions: In children aged 6-15 years, sub-chronic exposure to ambient PM2.5 and ozone leads to reduced lung capacity, whereas acute exposure to ozone decreases mid-expiratory flow. In children aged 6-10 years, additional airway obstructive patterns in lung function may be associated with PM2.5 exposure. ? 2014 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84918771851&doi=10.1016%2fj.envres.2014.11.021&partnerID=40&md5=f1b1ca01234fe9046a0768516ce80d2b https://scholars.lib.ntu.edu.tw/handle/123456789/475233 |
ISSN: | 0013-9351 | DOI: | 10.1016/j.envres.2014.11.021 | SDG/關鍵字: | ozone; air pollutant; ozone; particulate matter; asthma; atmospheric pollution; child health; data set; ozone; pollution exposure; adolescent; age; air monitoring; air pollutant; air pollution; airway obstruction; allergic rhinitis; ambient air; Article; body height; body weight; child; concentration (parameters); controlled study; cross-sectional study; female; forced expiratory volume; forced vital capacity; human; long term exposure; lung function; major clinical study; male; maximal mid expiratory flow; particulate matter; spirography; Taiwan; drug effects; exposure; forced expiratory flow; lung; lung function test; motor activity; particulate matter; pathophysiology; Respiratory Tract Diseases; sex difference; toxicity; vital capacity; Taiwan; Adolescent; Age Factors; Air Pollutants; Child; Cross-Sectional Studies; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Inhalation Exposure; Lung; Male; Motor Activity; Ozone; Particulate Matter; Respiratory Function Tests; Respiratory Tract Diseases; Sex Factors; Taiwan; Vital Capacity |
顯示於: | 環境職業醫學科 |
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